AZD-5363

Name: AZD-5363
SKU: A9601
Availability: InStock

Product ID A9601

Cas No. 1143532-39-1

Purity ≥99%, ≥99%ee

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

AZD-5363 is an oral pan-AKT inhibitor that causes hyperphosphorylation of AKT, locking it in a catalytically inactive state, unable to phosphorylate downstream signaling substrates such as PRAS40 and GSK-β. This compound displays anticancer chemotherapeutic activity, inhibiting proliferation and inducing tumor regression in in vitro and in vivo models of HER2+ breast cancer and prostate cancer. AZD-5363 may also exhibit inhibitory activity against Rho-associated protein kinase (ROCK), p70S6K, PKA, MKK1, MSK1, MSK2, PKC, PKG, PRKX, and RSK2/3.

Product Info

Cas No.	1143532-39-1
Purity	≥99%, ≥99%ee
Formula	C₂₁H₂₅ClN₆O₂
Formula Wt.	428.92
Chemical Name	4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidine-4-carboxamide
IUPAC Name	4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Synonym	AZD5363
Solubility	In DMSO(86mg/ml), water with 2 eq. of acid, insoulble on ethanol
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A9601 MSDS PDF
Info Sheet	A9601 Info Sheet PDF
Brochures	PI3K-Akt-mTORC Pathway Booklet

References

Addie M, Ballard P, Buttar D, et al. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem. 2013 Mar 14;56(5):2059-73. PMID: 23394218.

Lamoureux F, Thomas C, Crafter C, et al. Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. Clin Cancer Res. 2013 Feb 15;19(4):833-44. PMID: 23258740.

Davies BR, Greenwood H, Dudley P, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87. PMID: 22294718.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

AZD-5363

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

γ-Tocopherol

L-Carnitine

α-Zearalenol

VX-950

Rivaroxaban

Valdecoxib

Chloroquine Diphosphate

Gemifloxacin Mesylate

Foscarnet Sodium Hydrate

Diphenhydramine Hydrochloride

Acitretin

Salmeterol

Butoconazole Nitrate

Cyclosporin H

Dorsomorphin Dihydrochloride

7-Methyl-6-mercaptopurine

Protocatechuic Acid

D,L-α-Lipoic Acid

Flunisolide

BAY-1251152

Footer