LKT Labs

Biochemicals for Life Science Research

AZD-8055

AZD-8055

Product ID A9914
Cas No. 1009298-09-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $76.00 In stock
25 mg $245.00 In stock
50 mg $380.00 In stock
Bulk Quote

Quicklinks

Description

AZD-8055 is an ATP-competitive mTORC1/2 inhibitor that exhibits immunosuppressive and anticancer chemotherapeutic activities. AZD-8055 promotes antibody class switching in B cells at low doses and decreases B cell proliferation and differentiation at high doses. In vivo, this compound suppresses CC4+ and CD8+ T cell proliferation, increasing survival among MHC-mismatched heart transplant recipients. In vitro, AZD-8055 decreases viability of brain tumor cells; in vivo, it inhibits tumor growth.

Product Info

Cas No.

1009298-09-2
Purity

≥98%
Formula

C25H31N5O4
Formula Wt.

465.55
IUPAC Name

[5-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
Synonym

AZD-8055
Solubility

DMSO 50 mg/mL warmed (107.4 mM) Ethanol 3 mg/mL (6.44 mM) Water Insoluble
Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9914 MSDS PDF
Info Sheet

A9914 Info Sheet PDF

References

Limon JJ, So L, Jellbauer S, et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5076-85. PMID: 25385646.

Luchman HA, Stechishin OD, Nguyen SA, et al. Dual mTORC1/2 blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival. Clin Cancer Res. 2014 Nov 15;20(22):5756-67. PMID: 25316808.

Rosborough BR, Raïch-Regué D, Liu Q, et al. Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant. 2014 Sep;14(9):2173-80. PMID: 25307040.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V720004

    VS-4718

    Focal adhesion kinase (FAK) inhibitor.

    ≥99%
  • P1955

    Pentagastrin

    Synthetic peptide, stimulates gastric acid secr...

    ≥95%
  • T1754

    Tenatoprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • C5768

    Corazonin

    Neuropeptide found in insects.

    ≥95%
  • F1854

    Fenticonazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • N1894

    Nexturastat A

    HDAC6 inhibitor.

    ≥98%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • P3469

    Pirfenidone

    Collagen synthesis inhibitor.

    ≥98%
  • P7059

    Proxymetacaine Hydrochloride

    Potential voltage-gated Na+ channel blocker.

    ≥98%
  • H6225

    HPGDS-inhibitor-1

    HPGDS inhibitor.

    ≥98%
  • T1676

    L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • P3269

    Piroxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%
  • N5550

    Nomilin

    Triterpene found in species of Citrus; HIV-1 pr...

    ≥98%
  • A9617

    Azelnidipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • L1785

    Levofloxacin Hemihydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥98%