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Azelaic Acid

Azelaic Acid

Product ID A9817
Cas No. 123-99-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $41.00 In stock
25 g $71.50 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

Azelaic acid is a dicarboxylic acid originally found in Arabidopsis that exhibits anti-inflammatory activity. Azelaic acid is clinically used to treat rosacea, acne, and hyperpigmentary disorders. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARγ is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays anticancer potential as well, inhibiting the proliferation of cutaneous melanoma cells due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.

Product Info

Cas No.

123-99-9

Purity

≥98%

Formula

C9H16O4

Formula Wt.

188.22

Chemical Name

Nonanedioic acid

IUPAC Name

nonanedioic acid

Synonym

1,7-heptanedicarboxylic acid, Anchoic acid, Azelex

Melting Point

106.5°C

Solubility

Soluble in boiling water and alcohol

Appearance

A White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A9817 MSDS PDF

Info Sheet

A9817 Info Sheet PDF

References

Coda AB, Hata T, Miller J, et al. Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel. J Am Acad Dermatol. 2013 Oct;69(4):570-7. PMID: 23871720.

Briganti S, Flori E, Mastrofrancesco A, et al. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Exp Dermatol. 2013 Jan;22(1):41-7. PMID: 23278893.

Fitton A, Goa KL. Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs. 1991 May;41(5):780-98. PMID: 1712709.

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