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Baricitinib

Baricitinib

Product ID B022691
Cas No. 1187594-09-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $227.10 In stock
25 mg $746.20 In stock
50 mg $1,362.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Baricitinib is a selective and reversible inhibitor of JAK1 and JAK2. In an HIV-associated neurocognitive disorder murine model, baricitinib was found to cross the blood-brain barrier and accumulate to adequate concentrations to reduce HIV-induced inflammation.

Product Info

Cas No.

1187594-09-7

Purity

≥99%

Formula

C16H17N7O2S

Formula Wt.

371.42

Chemical Name

3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-

IUPAC Name

3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-

Synonym

INCB28050; LY3009104

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B022691 MSDS PDF

Info Sheet

B022691 Info Sheet PDF

References

Gavegnano C, Haile WB, Hurwitz S, et al. Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro. J Neuroinflammation. 2019 Sep 27;16(1):182. PMID: 31561750.

Murakami K, Kobayashi Y, Uehara S, et al. A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. PLoS One. 2017 Jul 14;12(7):e0181126. PMID: 28708884.

Ezzeldin E, Iqbal M, Asiri YA, et al. A hydrophilic interaction liquid chromatography-mass spectrometry quantitative method for determination of baricitinib in plasma, and its application in a pharmacokinetic study in rats. Molecules. 2020 Mar 31;25(7). pii: E1600. PMID: 32244454.

Fautrel B, Kirkham B, Pope JE, et al. Effect of baricitinib and adalimumab in reducing pain and improving function in patients with rheumatoid arthritis in low disease activity: exploratory analyses from RA-BEAM. J Clin Med. 2019 Sep 5;8(9): pii: E1394. PMID: 31492040.

Custom Order

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