Belinostat

Name: Belinostat
SKU: B1746
Availability: InStock

Product ID B1746

Cas No. 414864-00-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Belinostat is a histone deacetylase (HDAC) inhibitor that exhibits antiviral and anticancer chemotherapeutic activities. Belinostat is approved for use in humans in the treatment of T cell lymphoma and is currently in clinical trials as a potential treatment for other leukemias and lymphomas. In pancreatic cancer cells, belinostat induces apoptosis in an AMPK-dependent manner. In other cellular models, this compound decreases HIV release from macrophages by degrading intracellular HIV.

Product Info

Cas No.	414864-00-9
Purity	≥98%
Formula	C₁₅H₁₄N₂O₄S
Formula Wt.	318.35
IUPAC Name	(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
Synonym	PXD101
Solubility	DMSO 64 mg/mL (201.03 mM) Water Insoluble Ethanol Insoluble
Appearance	Pale yellow powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	B1746 MSDS PDF
Info Sheet	B1746 Info Sheet PDF

References

Campbell GR, Bruckman RS, Chu YL, et al. Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1. J Biol Chem. 2015 Feb 20;290(8):5028-40. PMID: 25540204.

Foss F, Advani R, Duvic M, et al. A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2014 Nov 17. [Epub ahead of print].
PMID: 25404094.

Kirschbaum MH, Foon KA, Frankel P, et al. A phase 2 study of belinostat (PXD101) in patients with relapsed or refractory acute myeloid leukemia or patients over the age of 60 with newly diagnosed acute myeloid leukemia: a California Cancer Consortium Study. Leuk Lymphoma. 2014 Oct;55(10):2301-4. PMID: 24369094.

Wang B, Wang XB, Chen LY, et al. Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis. Biochem Biophys Res Commun. 2013 Jul 19;437(1):1-6. PMID: 23743198.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Belinostat

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Pipemidic Acid

Prolylrapamycin

Metyrapone

Esculin

Imperatorin

SAR245409

Azelnidipine

Chalcone

Pyridoxine Hydrochloride

Anisomycin

Leptomycin B

ASTX660

Urocortin II, mouse

Neuropeptide FF

Gatifloxacin Sesquihydrate

Thienyldecyl Isothiocyanate

Leu-Enkephalin

10,13-Bissidechain Paclitaxel

Destruxin B

Quinapril Hydrochloride

Footer