• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Berberine Chloride

Berberine Chloride

Product ID B1870
Cas No. 633-65-8
Purity ≥97%
Product Unit SizeCostQuantityStock
5 g $59.50 In stock
10 g $81.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Berberine is an isoquinoline alkaloid found in a variety of plants, including barberry, goldenseal, Oregon grape, California poppy, and the Amur cork tree. Berberine fluoresces under ultraviolet light and is often used to stain heparin in mast cells. Berberine displays many beneficial effects, including immunomodulatory, anticancer, anti-inflammatory, antiviral, lipid-lowering, and antidepressant activities. This compound is a competitive inhibitor of both acetylcholinesterase (AChE) and prolyl oligopeptidase, enzymes important in neuropsychiatric disorders such as Alzheimer’s Disease, depression, schizophrenia, and anxiety. In animal models of depression, berberine increases levels of 5-HT, DA, and NE and is also thought to act on σ receptors. Berberine suppresses hedgehog (Hh) signaling, likely through inhibition of the Smoothened (Smo) receptor.

Product Info

Cas No.

633-65-8

Purity

≥97%

Formula

C20H18NO4 • Cl

Formula Wt.

371.82

IUPAC Name

16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride

Melting Point

200°C

Solubility

Soluble in boiling water. Slightly soluble in cold water. Soluble in methanol >20 mg/mL. Soluble in ethanol >2 mg/mL. Soluble in DMSO 74 mg/mL. Slightly soluble in chloroform.

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1870 MSDS PDF

Info Sheet

B1870 Info Sheet PDF

Brochures

Hedgehog Signaling Flyer

References

Wang J, Peng Y, Liu Y, et al. Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth. BMC Cancer. 2015 Aug 22;15:595.

Huang L, Shi A, He F, et al. Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. PMID: 20056426.

Tarrago T, Kichik N, Seguí J, et al. The natural product berberine is a human prolyl oligopeptidase inhibitor. ChemMedChem. 2007 Mar;2(3):354-9. PMID: 17295371.

Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res. 2010 Mar;24(3):317-24. PMID: 19998323.

Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chloride. Eur J Pharmacol. 2008 Jul 28;589(1-3):163-72. PMID: 18585703.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D364086

    Decernotinib

    JAK3 inhibitor.

    ≥99%
  • M5794

    Moxifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV, topoisomeras...

    ≥98%
  • P1755

    Pentoxifylline

    Xanthine derivative; adenosine A2 antagonist, P...

    ≥98%
  • G1310

    GDC-0349

    mTOR inhibitor.

    ≥98%
  • D3261

    Dipropyl Disulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • C000076

    C-176

    STING antagonist

    ≥99%
  • T8145

    Tulobuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • C086007

    CC-671

    TTK/CLK2 inhibitor.

    ≥98%
  • A7657

    Atosiban Acetate

    Peptide, alters uterine contractility; V1/2 and...

    ≥95%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B5075

    BMS-708163

    γ-Secretase inhibitor.

    ≥98%
  • F4679

    Flubendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • P6857

    Protocatechuic Acid

    Polyphenol found in many plants and foods.

    ≥97%
  • D0169

    Darifenacin Hydrobromide

    M3 mAChR antagonist.

    ≥98%
  • C0344

    Calphostin C

    Found in Cladosporium; PKC inhibitor.

    ≥95%
  • R176485

    Remdesivir

    SARS-CoV-2 inhibitor

    ≥99%
  • P698583

    Prostaglandin E2

    principal metabolic product of COX-2

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only