LKT Labs

Biochemicals for Life Science Research

Betamethasone Valerate

Betamethasone Valerate

Product ID B1879
Cas No. 2152-44-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 In stock
100 mg $245.30 In stock
500 mg $816.70 In stock
Bulk Quote

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Description

Betamethasone valerate (BMV) is a synthetic glucocorticoid that is commonly used to treat psoriasis and dermatitis. BMV exhibits immunomodulatory, anti-inflammatory, and vasoconstrictive activity in vitro and in vivo. Across animal models of varying ages, BMV impairs maturation and viability of Langerhans and epidermal cells. BMV also decreases endogenous phospholipase activity and inhibits vasodilatory responses in skin; this partial vasoconstriction decreases blood flow, often resulting in a decrease in local TGF-β1 levels.

Product Info

Cas No.

2152-44-5
Purity

≥98%
Formula

C27H37FO6
Formula Wt.

476.58
Chemical Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S, 17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13, 16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
Synonym

Betaderm, Betnovate
Melting Point

183.5°C
Solubility

Insoluble in water. Ethanol (62 mg/mL). Soluble in acetone, DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

B1879 MSDS PDF
Info Sheet

B1879 Info Sheet PDF

References

Naldi L, Yawalkar N, Kaszuba A, et al. Efficacy and safety of the Betamethasone valerate 0.1% plaster in mild-to-moderate chronic plaque psoriasis: a randomized, parallel-group, active-controlled, phase III study. Am J Clin Dermatol. 2011 Jun 1;12(3):191-201. PMID: 21284407.

Meindl S, Vaculik C, Meingassner JG, et al. Differential effects of corticosteroids and pimecrolimus on the developing skin immune system in humans and mice. J Invest Dermatol. 2009 Sep;129(9):2184-92. PMID: 19295616.

Leivo T, Arjomaa P, Oivula J, et al. Differential modulation of transforming growth factor-beta by betamethasone-17- valerate and isotretinoin: corticosteroid decreases and isotretinoin increases the level of transforming growth factor-beta in suction blister fluid. Skin Pharmacol Appl Skin Physiol. 2000 May-Aug;13(3-4):150-6. PMID: 10859533.

Marks R, Sawyer M. Glucocorticoid-induced vasoconstriction in human skin. An inhibitory role on phospholipase A2 activity. Arch Dermatol. 1986 Aug;122(8):881-3. PMID: 2874773.

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