Description
BI-2536 is a polo-like kinase 1 (PLK1) inhibitor that disrupts mitosis and cell division. BI-2536 exhibits anticancer activity and may induce apoptosis in cancer cells.
Product Unit Size | Cost | Quantity | Stock |
---|
BI-2536 is a polo-like kinase 1 (PLK1) inhibitor that disrupts mitosis and cell division. BI-2536 exhibits anticancer activity and may induce apoptosis in cancer cells.
Cas No. | 755038-02-9 |
---|---|
Purity | ≥98% |
Formula | C28H39N7O3 |
Formula Wt. | 521.65 |
IUPAC Name | 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide |
Synonym | BI2536 |
Solubility | Ethanol 100 mg/mL (191.69 mM) DMSO 21 mg/mL (40.25 mM) Water Insoluble |
Appearance | Pale yellow to off-white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Colnaghi R, Wheatley SP. Liaisons between survivin and Plk1 during cell division and cell death. J Biol Chem. 2010 Jul 16;285(29):22592-604. PMID: 20427271.
Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nature Reviews Cancer. 2009 Jan;9:28-39.
D-Seco Paclitaxel is an impurity in the product...
Vitamin D2, ergocalciferol metabolite; VDR agon...
Quaternary base alkaloid found in Phellodendron...
Hydroxypyridone, metal ion chelator; mTOR inhib...
Degrader of IKZF1/3
Immunodominant peptide fragment of PLP, used to...
AR antagonist.
Flavanone glycoside found in citrus fruit; SERM...
Cyclosporin metabolite; weak calmodulin inhibit...
Peptide fragment of VSV; LDLR agonist.
NS3/4A inhibitor
Retinoid, differentiation inducer.
Peptide; NMDA partial agonist.
Neurotoxin found in puffer fish; site 1 voltage...
Natriuretic, vasodilatory peptide; B1/2 agonist...
Organosulfur found in garlic.
Diphenylmethane, inhibits secretion of cortisol...
PKG inhibitor.
Alkaloid found in Galanthus, Narcissus, Leucoju...
Induces apoptosis, DNA cleavage and strand brea...