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Bleomycin A5 Hydrochloride

Bleomycin A5 Hydrochloride

Product ID B4517
Cas No. 55658-47-4
Purity ≥90%
Product Unit SizeCostQuantityStock
1 mg $121.30 In stock
5 mg $373.80 In stock
10 mg $654.90 In stock
25 mg $1,100.30 In stock
Bulk Quote

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  • Description
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Description

Bleomycin A5 is an anticancer chemotherapeutic that binds DNA and induces DNA cleavage and strand breaks; it is highly toxic. Bleomycin is clinically used to treat lymphomas, squamous cell carcinomas, and testicular cancer. Additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. Bleomycin may also inhibit thioredoxin reductase.

Product Info

Cas No.

55658-47-4

Purity

≥90%

Formula

C57H89N19O21S2 • HCl

Formula Wt.

1477.02

Chemical Name

Bleomycin A5 Hydrochloride

IUPAC Name

[2-[2-[2-[[6-amino-2-[3-amino-1-[(2, 3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl] amino]-3-[[5-[[1-[2-[4-[4-[3-(4-aminobutylamino)propylcarbamoyl]-1, 3-thiazol-2-yl]-1, 3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4- methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4, 5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3, 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate;hydrochloride InChI: InChI=1S/C57H89N19O21S2.ClH/c1-22-35(73-48(76-46(22)61)27(14-33(60)80) 68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39 (82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53 (91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98- 34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58;/h16,19-21,23-27, 31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60, 80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H, 75,90)(H2,61,73,76);1H

Synonym

Pingyangmycin hydrochloride

Solubility

Freely soluble in water, slightly soluble in ethanol

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

B4517 MSDS PDF

Info Sheet

B4517 Info Sheet PDF

References

Li P, Li DF, Guo ZT, et al. Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study. Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):18-22. PMID: 23534516.

Yang Y, Sun M, Ma Q, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. PMID: 20843632.

Liu Y, Wu F, Zou G. Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Anal Chim Acta. 2007 Sep 19;599(2):310-4. PMID: 17870295.

Vorobjev PE, Smith JB, Pyshnaya IA, et al. Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. PMID: 14624648.

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