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Bortezomib

Bortezomib

Product ID B5871
Cas No. 179324-69-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $112.60 In stock
25 mg $413.30 In stock
100 mg $939.10 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bortezomib is a proteasome inhibitor that displays anticancer chemotherapeutic and antiviral activity in vitro, in vivo, and in clinical settings; it is clinically used or in trials for treatment of glioma, acute lymphoblastic leukemia (ALL), mantle cell lymphoma, and multiple myeloma. In glioma cells, bortezomib induces activation of caspase 3 and apoptosis; its inhibition of the proteasome stimulates angiogenesis through an increase in production of VEGF and HIF-1α. In colorectal cancer cells, bortezomib increased levels of ROS, inducing G2/M phase cell cycle arrest. Additionally, bortezomib induces neuropathy, potentially through increasing polymerized tubulin levels in neurons. In models of Rift Valley Fever Virus, bortezomib decreases viral load by suppressing nonstructural S-segment protein formation of nuclear filaments.

Product Info

Cas No.

179324-69-7

Purity

≥98%

Formula

C19H25BN4O4

Formula Wt.

384.24

Chemical Name

[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl] amino]butyl]boronic acid

IUPAC Name

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl] amino]butyl]boronic acid

Synonym

Velcade, PS-341

Melting Point

124-140°C

Solubility

DMSO 77mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B5871 MSDS PDF

Info Sheet

B5871 Info Sheet PDF

References

Keck F, Amaya M, Kehn-Hall K, et al. Characterizing the effect of Bortezomib on Rift Valley Fever Virus multiplication. Antiviral Res. 2015 May 19. [Epub ahead of print]. PMID: 26001632.

Bota DA, Alexandru D, Keir ST, et al. Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis. J Neurosurg. 2013 Dec;119(6):1415-23. PMID: 24093630.

Staff NP, Podratz JL, Grassner L, et al. Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons. Neurotoxicology. 2013 Dec;39:124-31. PMID: 24035926.

Du XL, Chen Q. Recent advancements of bortezomib in acute lymphocytic leukemia treatment. Acta Haematol. 2013;129(4):207-14. PMID: 23295437.

Hong YS, Hong SW, Kim SM, et al. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. Int J Oncol. 2012 Jul;41(1):76-82. PMID: 22552540.

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