Brompheniramine Maleate

Name: Brompheniramine Maleate
SKU: B7058
Availability: InStock

Product ID B7058

Cas No. 980-71-2

Purity ≥98%

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Description

Brompheniramine is a halogenated antihistamine derivative of pheniramine that exhibits anticholinergic and neuromodulatory activities. Brompheniramine inhibits the H1 histamine receptor and also displays non-selective inhibition of muscarinic acetylcholine receptors (mAChRs). Brompheniramine inhibits histamine-induced vasodilation and also potentiates the effects of opioid analgesics. Additionally, brompheniramine is the parent compound of zimelidine, a selective serotonin reuptake inhibitor (SSRI) that exhibits antidepressant activity; zimelidine inhibits pre-synaptic 5-HT reuptake and may inhibit the serotonin transporter (SERT) or monoamine oxidase B (MAO-B).

Product Info

Cas No.	980-71-2
Purity	≥98%
Formula	C₁₆H₁₉BrN₂ • C₄H₄O₄
Formula Wt.	435.31
Chemical Name	3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
IUPAC Name	3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
Synonym	brompheniramine hydrogen maleate, parabromdylamine maleate, Veltane
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	B7058 MSDS PDF
Info Sheet	B7058 Info Sheet PDF

References

Egashira T, Takayama F, Yamanaka Y. The inhibition of monoamine oxidase activity by various antidepressants: differences found in various mammalian species. Jpn J Pharmacol. 1999 Sep;81(1):115-21. PMID: 10580379.

Yasuda SU, Yasuda RP. Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. PMID: 10212017.

Tatsumi M, Groshan K, Blakely RD, et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. PMID: 9537821.

Dachman WD, Bedarida G, Blaschke TF, et al. Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol. 1994 Mar;93(3):606-14. PMID: 8151062.

Ogren SO, Ross SB, Hall H, et al. The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta Psychiatr Scand Suppl. 1981;290:127-51. PMID: 6452789.

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Brompheniramine Maleate

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Description

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