LKT Labs

Biochemicals for Life Science Research

BVT-2733

BVT-2733

Product ID B8676
Cas No. 376640-41-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $118.00 In stock
25 mg $481.20 In stock
Bulk Quote

Quicklinks

Description

BVT-2733 is an inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) that exhibits anti-diabetic, anti-inflammatory, and anti-osteoporotic properties. BVT-2733 decreases blood glucose and serum insulin levels in animal models of hyperglycemia. BVT-2733 also attenuates arthritis severity, decreases pro-inflammatory cytokine production, and suppresses synovial inflammation. In other animal models, this compound prevents 11βHSD-induced osteogenic differentiation and suppression of osteogenesis.

Product Info

Cas No.

376640-41-4
Purity

≥98%
Formula

C17H21ClN4O3S2
Formula Wt.

428.96
Chemical Name

3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
IUPAC Name

3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
Synonym

BVT2733
Solubility

40mg/ml in DMSO

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B8676 MSDS PDF
Info Sheet

B8676 Info Sheet PDF

References

Zhang L, Dong Y, Zou F, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. PMID: 23938253.

Wu L, Qi H, Zhong Y, et al. 11β-Hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. Endocr J. 2013;60(9):1047-58. PMID: 23759754.

Alberts P, Engblom L, Edling N, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002 Nov;45(11):1528-32. PMID: 12436336.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P3561

    Piperlongumine

    Found in Piper longum; TxA2 antagonist, ubiquit...

    ≥98%
  • H1662

    HER2/neu (654-662) GP2

    Peptide fragment of HER2/neu/erbB2 receptor.

    ≥95%
  • A2501

    AG-1517

    EGFR inhibitor.

    ≥98%
  • C0033

    Cafestol Stearate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • O486179

    Omeprazole Impurity C

    Impurity of omeprazole

    ≥99%
  • S9753

    Synephrine

    Endogenous alkaloid also found in citrus fruits...

    ≥98%
  • T8000

    Tubacin

    HDAC6 inhibitor.

    ≥96%
  • N582686

    L-(-)-Norepinephrine-(+)-bitartrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • I7468

    Isradipine

    Calcium channel blocker.

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • D1768

    Dermaseptin I

    Cationic antimicrobial peptide, alters bacteria...

    ≥96%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • B6802

    Bradykinin (1-3)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • M1826

    Meglumine

    Amino sugar, sorbitol derivative, used as a bul...

    ≥98%
  • G8225

    Guggulsterone

    Steroid found in myrrh; FXR antagonist.

    ≥98%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.

    ≥97%
  • G4479

    Glucagon (19-29), human

    Endogenous peptide hormone, glugagon fragment; ...

    ≥95%
  • C1633

    Cefotaxime Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥96%
  • A6982

    Artesunate

    Sesquiterpene lactone derived from Artemesia.

    ≥98%