Description
BX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth.
BX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth.
| Cas No. | 702675-74-9 |
|---|---|
| Purity | ≥98% |
| Formula | C23H26IN7O2S |
| Formula Wt. | 591.47 |
| Chemical Name | N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide |
| IUPAC Name | N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide |
| Synonym | BX795 |
| Solubility | DMSO 100 mg/mL (169.07 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Feldman RI, Wu JM, Polokoff MA, et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. PMID: 15772071.
MEK1/2 inhibitor.
Decreases expression of MMPs, PGE2, and COX-2, ...
Triterpenoid found in Centella.
Flavone found in Passiflora, Oroxylum, and Pleu...
Triterpene saponin found in species of Panax.
Selective inhibitor of protein kinase C (PKC).<...
Cell-membrane permeable heterocyclic light-emit...
Triazole; 14α demethylase inhibitor.
Polypeptide; peptidoglycan inhibitor.
Mycotoxin produced by Alternaria; oxidative pho...
Variety of flavonoid found in various plant sou...
Alkylamine; histamine H1 antagonist, SERT and N...
Fermentation impurity
Endogenous peptide hormone fragment, involved i...
FabI inhibitor
STING agonist
Alkaloid found in Corydalis and Stephania; D1/2...
Imidazole; 14-α demethylase inhibitor, potenti...
Sulforaphane-cysteine conjugate.
Marine toxin; actin polymerization inducer.