Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
Cas No. | 1243243-89-1 |
---|---|
Purity | ≥98% |
Formula | C25H21N3O |
Formula Wt. | 379.45 |
Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
Synonym | Wnt-C59 |
Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
Nucleotide (guanine) analog, prevents guanine s...
Nucleoside (guanosine) analog; RT, guanylyl cyc...
EGFR inhibitor.
VEGFR2, c-Met, RET inhibitor.
Isoflavone found in legumes such as soy.
RORα/γ inverse agonist.
Morpholine derivative.
Thiazolidine macrolide found in the Red Sea spo...
Synthesis impurity
Naturally occuring isothiocyanate found in broc...
Mouse selective STING agonist.
Histamine H2 antagonist.
Serum response factor inhibitor and MRTF-A bind...
β-lactam; penicillin binding protein inhibitor...
Taxane found in Taxus; DNA polymerase inhibitor...
Non-proteinogenic amino acid, L-arginine metabo...
Benzothiazole; TRPC5 agonist, PTR1 inhibitor, v...
NSAID; TREK1 K+ potentiator, voltage-gated Na+ ...
Endogenous steroid hormone involved in immune r...