Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
| Cas No. | 1243243-89-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H21N3O |
| Formula Wt. | 379.45 |
| Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| Synonym | Wnt-C59 |
| Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
Cyclic hexadepsipeptide mycotoxin produced by C...
Alkaloid originally found in species of Nicotia...
Fluoroquinolone; topoisomerase IV and bacterial...
An omega-3 fatty acid.
Cannabinoid receptor 2 selective agonist.
Pt-based DNA cross-linker.
Promotes degradation of cIAP1
p110δ and p110γ PI3K inhibitor.
Peptide fragment, renin substrate, precursor to...
Alkaloid found in Sinomenium; acid-sensing ion ...
Aminoglycoside; protein translation inhibitor, ...
Immunodominant peptide epitope occurring in mul...
Endogenous pteridine metabolite of GTP.
Ca2+ ionophore.
SIRT inhibitor.
Potential voltage-gated Na+ channel blocker.
H1 histamine and LT antagonist, PDE inhibitor.<...
Building block
PAK4 inhibitor.
Triazole; 14-α demethylase and aromatase inhib...