Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
Cas No. | 1243243-89-1 |
---|---|
Purity | ≥98% |
Formula | C25H21N3O |
Formula Wt. | 379.45 |
Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
Synonym | Wnt-C59 |
Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
Pt-based DNA cross-linker.
Cysteine-ITC conjugate, antioxidant; aldehyde d...
Type A trichothecene mycotoxin produced by Fusa...
FIASMA, 5-HT3 and σ1 agonist, SERT inhibitor.<...
Benzimidazole; microtubule polymerization inhib...
Diterpene found in Taxus.
GABA-A positive modulator.
Ca2+ sensitizer; ATP-sensitive K+ channel activ...
Coenzyme, vitamin found in dairy, meat, eggs, f...
ACE inhibitor.
Fluoroquinolone; topoisomerase IV, topoisomeras...
Dihydroxyphenolic acid found in cruciferous veg...
Induces activation of Nrf2; inhibits apoptosis ...
H+/K+ ATPase inhibitor.
Aminoglycoside; protein translation inhibitor, ...
BH3 mimetic; Bcl-2 inhibitor.
Triazole; 14-α demethylase and aromatase inhib...
EGFR inhibitor.
Aspirin analog; hemoglobin chain cross-linker.<...
Jumonji histone demethylase inhibitor.