Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
Cas No. | 1243243-89-1 |
---|---|
Purity | ≥98% |
Formula | C25H21N3O |
Formula Wt. | 379.45 |
Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
Synonym | Wnt-C59 |
Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...
1-Naphthalenacetic acid derivative, NSAID; COX-...
Recombinant HIV glycoprotein antigen fragment.<...
Immunostimulator, adjuvant.
Endogenous NMDA receptor antagonist.
Semi-synthetic derivative of chlorophyll; food ...
Nitrosourea, DNA cross-linker.
ITC, erysolin analog.
Neuraminidase inhibitor.
Endogenous quaternary ammonium, required for fa...
Neuroactive mycotoxin produced by Penicillum an...
COMT inhibitor.
Antineoplastic immunomodulator.
EGFR inhibitor.
Microtubule depolymerization inhibitor.
Mycotoxin produced by various fungi including t...
Calcium channel blocker.
α1-Adrenergic antagonist.
Triterpene saponin found in Bupleurum.
Polyphenol found in various plant sources, resv...