Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
| Cas No. | 1243243-89-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H21N3O |
| Formula Wt. | 379.45 |
| Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| Synonym | Wnt-C59 |
| Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
FAAH inhibitor.
Endogenous opioid peptide; μOR agonist.
Cysteine-ITC conjugate.
Macrolide; threonyl-tRNA synthetase/ligase inhi...
Nitrosourea, DNA alkylator.
Resveratrol prodrug; potential SIRT1 activator....
Snake venom cardiotoxin found in Naja naja atra...
Mycotoxin produced by Aspergillus; BK K+ channe...
p110α PI3K, DNA-PK, mTOR, Abl, Hck, Src, VEGFR...
Wee1 inhibitor.
Peptide, used as control to measure RGDS peptid...
Macrolide lactone antibiotic.
Polymethoxylated flavone found in citrus fruits...
Peptide, involved in neutrophil activation; FPR...
Aromatase inhibitor.
Induces activation of Nrf2; inhibits apoptosis ...
Amino amide; voltage-gated Na+, BK/SK, Kv1, Kv3...
Organosulfide found in Allium; cholesterol synt...
NSAID; COX-1/2 inhibitor.
Stem cell neurogenesis inducer.