Description
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
C59 is a PORCN inhibitor that exhibits anticancer chemotherapeutic activity, inhibiting the progression of mammary tumors in vivo by downregulating Wnt signaling.
| Cas No. | 1243243-89-1 |
|---|---|
| Purity | ≥98% |
| Formula | C25H21N3O |
| Formula Wt. | 379.45 |
| Chemical Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| IUPAC Name | 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide |
| Synonym | Wnt-C59 |
| Solubility | DMSO 76 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. PMID: 23188502.
PDE and adenosine deaminase inhibitor.
Benzimidazole; microtubule polymerization inhib...
Pyrimidine derivative; kinesin Eg5 inhibitor.
Peptide, confers resistance against macrolide a...
Triazine, melamine derivative, insect growth re...
Expectorant.
Found in Taxus, starting material for synthesis...
Derivative of aristolochic acid found in Asarum...
Recombinant chimeric protein containing Trepone...
HIV and AIDS
Potential PKD binding agent.
Aurora kinase A inhibitor
Naturally occuring isothiocyanate found in broc...
Toll-like receptor 7/8 agonist
Sulfonamide; folate production inhibitor.
Smoothened agonist.
Endogenous pterin coenzyme required for release...
A peroxisome proliferator-activated receptor ag...
Phenol found in the creosote bush; 5-lipoxygena...
Diphenylmethane, inhibits secretion of cortisol...