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Caffeine

Caffeine

Product ID C0221
Cas No. 58-08-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $48.30 In stock
50 g $120.20 In stock
100 g $180.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Caffeine is a xanthine alkaloid found in coffee, tea, and many other plant sources; it exhibits stimulant, bronchodilatory, anti-asthma, vasoconstrictive, anti-inflammatory, antioxidative, anti-aging, and anti-fibrotic activities. Caffeine activates adenosine receptors and inhibits phosphodiesterases (PDEs), increases levels of cAMP, activating PKA, and inhibiting the release of TNF-α and leukotrienes. In clinical settings, caffeine administration increases FEV1. Caffeine may decrease UV radiation-dependent skin damage, protecting against skin aging. Increases in caffeine consumption in human subjects are associated with decreases in risk for cardiovascular and neurological diseases. In animal models of fibrosis, caffeine decreases release of STGF, collagen I, TNF-α, IL-6, IL-1, and TGF-β1, preventing fibrosis.

Product Info

Cas No.

58-08-2

Purity

≥98%

Formula

C8H10N4O2

Formula Wt.

194.19

Chemical Name

3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

IUPAC Name

1,3,7-trimethylpurine-2,6-dione

Synonym

Coffeine, Thein, Guaranine, Methyltheobromine, No-Doz

Melting Point

238°C

Solubility

Soluble in ethyl acetate or pyrrole. Slightly soluble in water (20 mg/mL), solubility is increased by adding dilute acid. Slightly soluble in ethanol (13 mg/mL).

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0221 MSDS PDF

Info Sheet

C0221 Info Sheet PDF

References

Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int. 2014 Apr;14(2):430-9. PMID: 23879665.

Gordillo-Bastidas D, Oceguera-Contreras E, Salazar-Montes A, et al. Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine. World J Gastroenterol. 2013 Dec 21;19(47):9020-33. PMID: 24379627.

Herman A, Herman AP. Caffeine's mechanisms of action and its cosmetic use. Skin Pharmacol Physiol. 2013;26(1):8-14. PMID: 23075568.

Ribeiro JA, Sebastião AM. Caffeine and adenosine. J Alzheimers Dis. 2010;20 Suppl 1:S3-15. PMID: 20164566.

Welsh EJ, Bara A, Barley E, et al. Caffeine for asthma. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001112. PMID: 20091514.

Custom Order

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