• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Candesartan Celexetil Ester

Candesartan Celexetil Ester

Product ID C0254
Cas No. 145040-37-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $101.00 In stock
250 mg $180.00 In stock
1 g $546.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Candesartan is an inhibitor of the angiotensin II type 1 receptor (AT1) that displays antihypertensive, cardioprotective, nephroprotective, and potentially antiviral activities. In vivo, candesartan increases renal blood blow and decreases renal vascular resistance, glomerular filtration rate, and filtration fraction. Candesartan also decreases NADPH oxidase activity and levels of TGF-β, inhibiting calcium oxalate crystal deposition and kidney stone formation. In animal models of pressure overload-induced cardiac remodeling, candesartan downregulates Smad3 and fibronectin, upregulates Smad7, and inhibits matrix metalloproteinase 9 (MMP9) and the epithelial-to-mesenchymal transition (EMT), preventing collagen deposition, left ventricular remodeling, and decreases in left ventricular ejection fraction. Additionally, this compound downregulates expression of VEGFR2, decreasing retinal neovascularization without inhibiting total angiogenesis. Separately, candesartan may inhibit the interaction between lens epithelium-derived growth factor (LEDGF) and HIV-1 integrase, exhibiting potential as a treatment for HIV.

Product Info

Cas No.

145040-37-5

Purity

≥98%

Formula

C33H34N6O6

Formula Wt.

610.66

Chemical Name

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole- 4-carboxylate

IUPAC Name

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole- 4-carboxylate

Synonym

Candesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester

Solubility

Chloroform, slightly soluble in methanol, ethanol (3 mg/ml), DMSO (30 mg/ml).

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0254 MSDS PDF

Info Sheet

C0254 Info Sheet PDF

Brochures

Antivirals Booklet

References

Patinha D, Fasching A, Pinho D, et al. Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F614-22. PMID: 23283998.

Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.

Nakamura S, Tsuruma K, Shimazawa M, et al. Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. Eur J Pharmacol. 2012 Jun 15;685(1-3):8-14. PMID: 22543084.

Yu H, Zhao G, Li H, et al. Candesartan antagonizes pressure overload-evoked cardiac remodeling through Smad7 gene-dependent MMP-9 suppression. Gene. 2012 Apr 15;497(2):301-6. PMID: 22326534.

Yoshioka I, Tsujihata M, Akanae W, et al. Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys. Urology. 2011 Apr;77(4):1007.e9-1007.e14. PMID: 21256551.

Wada T, Inada Y, Ojima M, et al. Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res. 1996 Jun;19(2):75-81. Erratum in: Hypertens Res 1996 Sep;19(3):221. PMID: 10968199.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • K0652

    Kb NB 142-70

    PKD inhibitor.

    ≥98%
  • P9671

    Pyrazinamide

    Nicotinamide analog prodrug; fatty acid synthet...

    ≥98%
  • P0268

    Parasin I

    Histone H2-derived antimicrobial peptide found ...

    ≥95%
  • E0073

    Ebselen

    Synthetic glutathione peroxidase mimetic; yeast...

    ≥99%
  • K0040

    Kahweol Stearate

    Diterpene found in coffee beans.

    ≥98%
  • K040009

    KB-0742 dihydrochloride

    CDK9 inhibitor.

    ≥99%
  • F4780

    Fluoxetine Hydrochloride

    FIASMA, SERT inhibitor, 5-HT and σ1 antagonist...

    ≥98%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • M1749

    Memantine Hydrochloride

    D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist.<...

    ≥97%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • C2947

    Chlorpromazine Hydrochloride

    Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 mAC...
    ≥98%
  • A6971

    ARRY-162

    MEK1/2 and ERK inhibitor.

    ≥99%
  • S8247

    Sulfasalazine

    Mesalazine derivative, sulfa drug; sepiapterin ...

    ≥98%
  • V3327

    Virginiamycin Mixture

    Macrolide antibiotic

    ≥97%
  • R2710

    Recombinant Multi-epitope Chimeric HCV Antigen

    Recombinant Multi-epitope Chimeric HCV antigen....

    ≥95%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • A2044

    Aflatoxin B1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%
  • D1769

    Dermorphin

    Opioid peptide; μOR agonist.

    ≥96%
  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only