LKT Labs

Biochemicals for Life Science Research

Candesartan Celexetil Ester

Product ID C0254
Cas No. 145040-37-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $77.80 In stock
250 mg $138.60 In stock
1 g $421.40 In stock
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Description

Candesartan is an inhibitor of the angiotensin II type 1 receptor (AT1) that displays antihypertensive, cardioprotective, nephroprotective, and potentially antiviral activities. In vivo, candesartan increases renal blood blow and decreases renal vascular resistance, glomerular filtration rate, and filtration fraction. Candesartan also decreases NADPH oxidase activity and levels of TGF-β, inhibiting calcium oxalate crystal deposition and kidney stone formation. In animal models of pressure overload-induced cardiac remodeling, candesartan downregulates Smad3 and fibronectin, upregulates Smad7, and inhibits matrix metalloproteinase 9 (MMP9) and the epithelial-to-mesenchymal transition (EMT), preventing collagen deposition, left ventricular remodeling, and decreases in left ventricular ejection fraction. Additionally, this compound downregulates expression of VEGFR2, decreasing retinal neovascularization without inhibiting total angiogenesis. Separately, candesartan may inhibit the interaction between lens epithelium-derived growth factor (LEDGF) and HIV-1 integrase, exhibiting potential as a treatment for HIV.

Product Info

Cas No.

145040-37-5
Purity

≥98%
Formula

C33H34N6O6
Formula Wt.

610.66
IUPAC Name

1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole- 4-carboxylate
Synonym

Candesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Solubility

Chloroform, slightly soluble in methanol, ethanol (3 mg/ml), DMSO (30 mg/ml).
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C0254 MSDS PDF
Info Sheet

C0254 Info Sheet PDF
Brochures

Antivirals Booklet

References

Patinha D, Fasching A, Pinho D, et al. Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F614-22. PMID: 23283998.

Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.

Nakamura S, Tsuruma K, Shimazawa M, et al. Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. Eur J Pharmacol. 2012 Jun 15;685(1-3):8-14. PMID: 22543084.

Yu H, Zhao G, Li H, et al. Candesartan antagonizes pressure overload-evoked cardiac remodeling through Smad7 gene-dependent MMP-9 suppression. Gene. 2012 Apr 15;497(2):301-6. PMID: 22326534.

Yoshioka I, Tsujihata M, Akanae W, et al. Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys. Urology. 2011 Apr;77(4):1007.e9-1007.e14. PMID: 21256551.

Wada T, Inada Y, Ojima M, et al. Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res. 1996 Jun;19(2):75-81. Erratum in: Hypertens Res 1996 Sep;19(3):221. PMID: 10968199.

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