Description
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Cas No. | 976-71-6 |
---|---|
Purity | ≥98% |
Formula | C22H28O3 |
Formula Wt. | 340.46 |
Chemical Name | (17α)-17-Hydroxy-3-oxo-pregna-4,6-diene-21- carboxylic acid γ-lactone |
IUPAC Name | 10,13-dimethylspiro[2,8,9,11,12,14,15, 16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione |
Synonym | Phanurane |
Melting Point | 149-151°C |
Appearance | Light yellow crystal powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Cargnelli G, Trevisi L, Debetto P, et al. Effects of canrenone on aorta and right ventricle of the rat. J Cardiovasc Pharmacol. 2001 May;37(5):540-7. PMID: 11336105.
Corvol P, Claire M, Oblin ME, et al. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. PMID: 7029118.
Synthetic peptide hormone.
Islet α/β cell proliferation stimulator.
STING antagonist
β1/2-adrenergic agonist.
Glucose metabolism inhibitor, N-linked glycosyl...
Peptide; galanin antagonist.
Dual inhibitor of PI3K and mTOR.
Microtubule depolymerization inhibitor.
Inhibits HCV replication
Triterpene saponin found in Bupleurum.
Walrycin response regulator inhibitor.
Endogenous proneurotensin peptide, involved in ...
Endogenous peptide, cleavage product of angiote...
Glutamine analog; γ-glutamyl transferase, CTP ...
Purine nucleotide analog, mercaptiopurine prodr...
Peptide hormone found in Solanaceae family plan...
Non-nitrogen bisphosphonate; mitochondrial ATP/...
EZH2 HMT inhibitor.
Marine toxin; actin polymerization inducer.
SERCA inhibitor.