Description
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
Cas No. | 976-71-6 |
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Purity | ≥98% |
Formula | C22H28O3 |
Formula Wt. | 340.46 |
Chemical Name | (17α)-17-Hydroxy-3-oxo-pregna-4,6-diene-21- carboxylic acid γ-lactone |
IUPAC Name | 10,13-dimethylspiro[2,8,9,11,12,14,15, 16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione |
Synonym | Phanurane |
Melting Point | 149-151°C |
Appearance | Light yellow crystal powder |
Store Temp | 4°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet |
Cargnelli G, Trevisi L, Debetto P, et al. Effects of canrenone on aorta and right ventricle of the rat. J Cardiovasc Pharmacol. 2001 May;37(5):540-7. PMID: 11336105.
Corvol P, Claire M, Oblin ME, et al. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. PMID: 7029118.
Synthesis impurity
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