• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Carbenoxolone

Carbenoxolone

Product ID C0167
Cas No. 5697-56-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $37.80 In stock
5 g $113.60 In stock
25 g $330.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Carbenoxolone is a synthetic derivative of the active component of licorice (Glycyrrhiza glabra) and is most well known for its ability to inhibit gap junction connexin channels and 11β-hydroxysteroid dehydrogenase. Carbenoxolone displays a wide variety of beneficial properties, including neuroprotective, anti-inflammatory, and anti-obesity activities. In animal models, carbenoxolone decreases stroke infarction size and neuronal damage after middle cerebral artery occlusion and also delays the onset of experimental autoimmune encephalitis (EAE), potentially by decreasing production of IL-23 and Th17 cells. Carbenoxolone also prevents atrial inflammation and atrial fibrillation by inhibiting macrophage migration into atria. This compound exudes several benefits in obese mice, inhibiting expression of sterol regulatory element binding protein 1c (SREBP1C) and preventing development of fatty liver disease. In vitro, carbenoxolone inhibits expression of pro-inflammatory cytokines and apoptotic proteins; it also prevents fatty acid-induced expression of ROS and reverses fatty acid-induced mitochondrial membrane depolarization. In high-fed diet mice, this compound decreases expression of GLUT4, PPAR-γ, and other lipid-regulating genes, resulting in decreased body weight and visceral fat mass and increased sensitivity to insulin.

Product Info

Cas No.

5697-56-3

Purity

≥98%

Formula

C34H50O7

Formula Wt.

570.76

Chemical Name

(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

IUPAC Name

(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

Synonym

Bioral

Melting Point

292.8°C

Solubility

100 mg/ 550 µL DMSO; 100 mg/ 3 mL Ethanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0167 MSDS PDF

Info Sheet

C0167 Info Sheet PDF

References

Beraki S, Litrus L, Soriano L, et al. A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke. PLoS One. 2013 Jul 18;8(7):e69233. PMID: 23874920.

Okuda H, Nishida K, Higashi Y, et al. NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci. 2013 Apr 19;92(13):808-14. PMID: 23454167.

Oishi S, Sasano T, Tateishi Y, et al. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J Pharmacol Sci. 2012;120(4):296-304. PMID: 23196902.

Rhee SD, Kim CH, Park JS, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. 2012 Sep 15;691(1-3):9-18. PMID: 22742899.

Sano S, Nakagawa Y, Yamaguchi R, et al. Carbenoxolone alters the morphology of adipose tissues and downregulates genes involved in adipogenesis, glucose transport and lipid metabolism in high-fat diet-fed mice. Horm Metab Res. 2012 Jan;44(1):15-20. PMID: 22205568.

Endong L, Shijie J, Sonobe Y, et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol. 2011 Dec 15;240-241:58-64. PMID: 22036952.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5846

    Tolfenamic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • K3352

    Kinetensin

    Peptide, neurotensin analog.

    ≥95%
  • C2540

    CGK 733

    ATM and ATR inhibitor.

    ≥98%
  • A5134

    Aminophylline Anhydrous

    Adenosine antagonist, PDE inhibitor.

    ≥98%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%
  • N5986

    Novobiocin Sodium

    Aminocoumarin; bacterial DNA gyrase inhibitor.<...

    ≥98%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • K0031

    Kahweol Acetate

    Diterpene found in coffee beans.

    ≥98%
  • P0254

    Panaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • B5871

    Bortezomib

    Proteasome inhibitor.

    ≥98%
  • M3598

    Mizoribine Hydrobromide

    IMPDH inhibitor.

    ≥98%
  • A2052

    Aflatoxin M1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • R0249

    Ramipril

    ACE inhibitor.

    ≥98%
  • M7530

    [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

    Semi-synthetic peptide, melanocortin analog; MC...

    ≥98%
  • G5875

    Gossypol Acetic Acid

    Bcl-2, Bcl-xl, sialyl transferase inhibitor.

    ≥98%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • P0253

    Panaxadiol

    Triterpene sapongenin found in species of Panax...

    ≥98%
  • P0245

    Palmatine Chloride Hydrate

    Isoquinoline alkaloid found in Corydalis, Phell...

    ≥96%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • S6129

    D-Sphingosine

    Endogenous component of sphingolipids; PKC inhi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only