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Carmofur

Carmofur

Product ID C0174
Cas No. 61422-45-5
Purity ≥97%
Product Unit SizeCostQuantityStock
250 mg $75.10 In stock
1 g $134.30 In stock
5 g $443.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Carmofur is a pyrimidine analog and derivative of fluorouracil; it exhibits anticancer chemotherapeutic and anti-metastatic activities. Carmofur inhibits thymidylate synthase and acid ceramidase, preventing DNA replication. This compound is clinically used to treat curatively resected colon cancer and breast cancer.

Product Info

Cas No.

61422-45-5

Purity

≥97%

Formula

C11H16FN3O3

Formula Wt.

257.26

Chemical Name

5-Fluoro-N-hexyl-3,4-dihydro-2,4-1(2H)- pyrimidinecarboxamide

IUPAC Name

5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide

Synonym

HCFU, Mifurol, Yamaful

Melting Point

110-111°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C0174 MSDS PDF

Info Sheet

C0174 Info Sheet PDF

References

Pizzirani D, Pagliuca C, Realini N, et al. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem. 2013 May 9;56(9):3518-30. PMID: 23614460.

Sakamoto J, Hamada C, Rahman M, et al. An individual patient data meta-analysis of adjuvant therapy with carmofur in patients with curatively resected colon cancer. Jpn J Clin Oncol. 2005 Sep;35(9):536-44. PMID: 16155120.

Morimoto K, Koh M. Postoperative adjuvant use of carmofur for early breast cancer. Osaka City Med J. 2003 Dec;49(2):77-83. PMID: 15179836.

Nakanishi H, Abe A, Inada K, et al. Induction of apoptosis in metastatic foci from human gastric cancer xenografts in nude mice and reduction of circulating tumor cells in blood by 5-FU and 1-hexylcarbamoyl-5-fluorouracil. J Cancer Res Clin Oncol. 1999 Dec;125(12):660-8. PMID: 10592098.

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