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Carmustine is a nitrosourea alkylator that is clinically used to treat brain cancers, multiple myeloma, and lymphomas. Carmustine exhibits anticancer chemotherapeutic and anticoagulant activities. Carmustine is often co-administered with MGMT inhibitors to increase its chemotherapeutic efficacy. In vitro and in vivo, carmustine also induces apoptosis in platelets, increasing bleeding time.
| Cas No. | 154-93-8 |
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| Purity | ≥98% |
| Formula | C5H9Cl2N3O2 |
| Formula Wt. | 214.05 |
| Chemical Name | N,N'-Bis(2-chloroethyl)-N-nitrosourea |
| IUPAC Name | 1,3-bis(2-chloroethyl)-1-nitrosourea |
| Synonym | Becenun, Bicnu, Carmubris |
| Melting Point | 30-32°C |
| Solubility | Soluble in water (4 mg/mL), 50% ethanol (150 mg/mL), DMSO. |
| Appearance | Yellowish Crystal |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Zhang J, Chen M, Zhang Y, et al. Carmustine induces platelet apoptosis. Platelets. 2014 Jun 23:1-6. [Epub ahead of print]. PMID: 24955606.
Drabløs F, Feyzi E, Aas PA, et al. Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. PMID: 15380096.