• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
CCT-128930

CCT-128930

Product ID C1176
Cas No. 885499-61-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $217.90 In stock
10 mg $398.20 In stock
25 mg $728.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CCT-128930 is a pyrrolopyrimidine that inhibits Akt and exhibits anticancer chemotherapeutic activity. In hepatoma cancer cells, this compound induces G1 phase cell cycle arrest, apoptosis, and autophagy, upregulates expression of p21, p27, and p53, and suppresses cell proliferation. CCT-128930 also induces G1 phase cell cycle arrest in glioblastoma cells and limits tumor growth in animal models with breast cancer xenografts.

Product Info

Cas No.

885499-61-6

Purity

≥98%

Formula

C18H20ClN5

Formula Wt.

341.84

Chemical Name

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

IUPAC Name

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

Synonym

CCT128930

Solubility

DMSO 68 mg/mL Ethanol 6 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C1176 MSDS PDF

Info Sheet

C1176 Info Sheet PDF

References

Wang FZ, Chang ZY, Fei HR, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014 Aug;103:118-25. PMID: 24793486.

Yap TA, Walton MI, Hunter LJ, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71. PMID: 21191045.

Caldwell JJ, Davies TG, Donald A, et al. Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. J Med Chem. 2008 Apr 10;51(7):2147-57. PMID: 18345609.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H189921

    1,2,3,4,5,6-Hexabromocyclohexane

    JAK2 inhibitor

    ≥98%
  • I5215

    Indolicidin

    Antimicrobial peptide.

    ≥95%
  • G3455

    Ginsenoside Rc

    Triterpene saponin found in species of Panax; A...

    ≥98%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • L960006

    LY-2606368

    CHK1 inhibitor.

    ≥98%
  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • A5170

    Amrinone

    Pyridine; PDE3 inhibitor.

    ≥98%
  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • B4402

    Blasticidin S Hydrochloride

    Protein translation inhibitor.

    ≥98%
  • C7997

    C-Type Natriuretic Peptide (1-22), human

    Endogenous cardiomodulatory peptide; NPR-B agon...

    ≥95%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • D004098

    Dacomitinib Anhydrous

    EGFR inhibitor.

    ≥99%
  • A4440

    Allicin

    Organosulfur found in garlic, binds DNA; inward...

    ≥98%
  • U698578

    Urolithin C

    Ellagic acid derivative produced by gut microfl...

    ≥98%
  • O6805

    Orbifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥99%
  • D8014

    DU-14

    Steroid sulfatase inhibitor.

    ≥98%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only