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Ciprofibrate

Ciprofibrate

Product ID C3260
Cas No. 52214-84-3
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $81.70 In stock
100 mg $224.60 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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Description

Ciprofibrate is a PPARα agonist that exhibits anti-hyperlipidemic activity. Clinically, ciprofibrate decreases levels of triglycerides and total cholesterol and increases levels of HDL. In hepatoma cells, ciprofibrate increases NF-κB DNA binding activity. Additionally, ciprofibrate induces depolarization of the mitochondrial membrane potential, which may be involved in its mechanism of enhancing peroxisome proliferation.

Product Info

Cas No.

52214-84-3

Purity

≥98%

Formula

C13H14Cl2O3

Formula Wt.

289.16

IUPAC Name

2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Melting Point

114-120°C

Solubility

Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene

Appearance

White or Light Yellow Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C3260 MSDS PDF

Info Sheet

C3260 Info Sheet PDF

References

Aguilar-Salinas CA, Assis-Luores-Vale A, Stockins B, et al. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study). Cardiovasc Diabetol. 2004 Jul 23;3:8. PMID: 15272932.

Li Y, Glauert HP, Spear BT. Activation of nuclear factor-kappaB by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells and its inhibition by the antioxidants N-acetylcysteine and vitamin E. Biochem Pharmacol. 2000 Feb 15;59(4):427-34. PMID: 10644051.

Zhou S, Wallace KB. The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicol Sci. 1999 Mar;48(1):82-9. PMID: 10330687.

Custom Order

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