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CK-636 is an inhibitor of actin-related protein 2/3 (Arp2/3); it binds between Arp2 and Arp3 to prevent the association of the two into their active conformation, limiting the formation of lamellipodia and cellular movement. CK-636 inhibits the production of tight junctions, cell-cell adhesion, and epidermal differentiation in vitro. This compound is used to study cellular movement and path finding in vitro.
| Cas No. | 442632-72-6 |
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| Purity | ≥98% |
| Formula | C16H16N2OS |
| Formula Wt. | 284.38 |
| IUPAC Name | N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
| Synonym | CK636, CK-0944636 |
| Solubility | DMSO 57 mg/mL (200.43 mM) Ethanol 50 mg/mL (175.82 mM) Water Insoluble |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhou K, Muroyama A, Underwood J, et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9. PMID: 24043783.
Kwon KW, Park H, Doh J. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960. PMID: 24069255.
Nolen BJ, Tomasevic N, Russell A, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. PMID: 19648907.