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Clofibrate is a fibrate compound that exhibits anti-hyperlipidemic and anticancer activities. Clofibrate acts as an agonist at PPARα, increasing lipoprotein lipase and HDL and decreasing triglycerides and VLDL. In leukemia cells, clofibrate induces G0/G1 phase cell cycle arrest and differentiation, decreases levels of c-myb and cyclin D2, and inhibits cellular growth.
| Cas No. | 637-07-0 |
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| Purity | ≥99% |
| Formula | C12H15ClO3 |
| Formula Wt. | 242.70 |
| Chemical Name | 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester |
| IUPAC Name | ethyl 2-(4-chlorophenoxy)-2-methylpropanoate |
| Synonym | Amotril, Apolan, Ateriosan, Claripex, CPIB, Liprinal, Normet, Recolip, Xyduril |
| Melting Point | <25°C |
| Solubility | Soluble in DMSO or ethanol. Insoluble in water. |
| Appearance | Golden-Yellow Liquid |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Laurora S, Pizzimenti S, Briatore F, et al. Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. PMID: 12649303.
Nicholls-Grzemski FA, Calder IC, Priestly BG, et al. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicol Sci. 2000 Jul;56(1):220-8. PMID: 10869471.