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Colistin Sulfate

Colistin Sulfate

Product ID C5647
Cas No. 1264-72-8
Purity Biological Potency: ≥19366 IU/mg
Product Unit SizeCostQuantityStock
100 mg $45.30 In stock
500 mg $67.80 In stock
1 g $82.70 In stock
5 g $97.70 In stock
25g $263.00 In stock
100g $480.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Colistin is an antimicrobial peptide (AMP); it is a polymixin-family antibiotic initially produced by species of Bacillus. Colistin displays antibacterial efficacy against gram negative bacteria, interacting with the bacterial outer membrane, inducing the formation of pores. This peptide also inhibits NADH quinone oxidoreductase. Colistin is no longer commonly used due to associated neurotoxicity and nephrotoxicity.

Product Info

Cas No.

1264-72-8

Purity

Biological Potency: ≥19366 IU/mg

Formula

C53H100N16O13 •x H2O4S (A)

Formula Wt.

1169.4

IUPAC Name

N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide

Synonym

Belcomycin, Colomycin syrup, Polymyxin E Complex

Solubility

Soluble in water (50 mg/mL).

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C5647 MSDS PDF

Info Sheet

C5647 Info Sheet PDF

References

Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.

Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.

Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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