LKT Labs

Biochemicals for Life Science Research

Coumestrol

Product ID C5680
Cas No. 479-13-0
Purity ≥96%
Product Unit SizeCostQuantityStock
10 mg $208.40 In stock
25 mg $347.30 In stock
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Description

Coumestrol is a phytoestrogen found in various plant sources such as soy, spinach, and clover; it exhibits estrogenic, anti-inflammatory, immunomodulatory, anti-osteoporotic, and antidepressant activities. Coumestrol acts as an agonist at ERβ and inhibits aromatase and 3α-hydroxysteroid dehydrogenase. Coumestrol decreases immobility in animals undergoing the forced swim test. Additionally, this compound decreases levels of TNF-α, IL-1β, IL-6, and RANKL, limits T cell differentiation and activation, and suppresses formation of osteoclasts in vitro.

Product Info

Cas No.

479-13-0
Purity

≥96%
Formula

C15H8O5
Formula Wt.

268.2
Chemical Name

3,9-Dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6- one
IUPAC Name

3,9-dihydroxy-[1]benzofuro[3,2-c]chromen-6-one
Synonym

Cumoesterol, Cumoestrol, Cumostrol

Melting Point

385°C
Solubility

Insoluble in water. Slightly soluble in methanol, ethanol or chloroform.
Appearance

Light Brown Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C5680 MSDS PDF
Info Sheet

C5680 Info Sheet PDF

References

Karieb S, Fox SW. Suppression of T cell-induced osteoclast formation. Biochem Biophys Res Commun. 2013 Jul 12;436(4):619-24. PMID: 23764400.

Blomquist CH, Lima PH, Hotchkiss JR. Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids. Steroids. 2005 Jul;70(8):507-14. PMID: 15894034.

Walf AA, Rhodes ME, Frye CA. Antidepressant effects of ERbeta-selective estrogen receptor modulators in the forced swim test. Pharmacol Biochem Behav. 2004 Jul;78(3):523-9. PMID: 15251261.

Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 1998 Oct;139(10):4252-63. PMID: 9751507.

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