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CTAP is an antagonist at μ-opioid receptors (μORs) that exhibits neuromodulatory activity. CTAP prevents reinstatement of drug seeking in animal models of ethanol addiction. CTAP also prevents opioid-induced decreases in inflammatory cytokine release in animal models of intestinal ischemia/reperfusion. Additionally, CTAP inhibits opioid-induced analgesia in animal models of colorectal distension.
| Cas No. | 103429-32-9 |
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| Purity | ≥95% |
| Formula | C51H67N13O11S |
| Formula Wt. | 1102.33 |
| IUPAC Name | (4R,7S,10S,13S,16S,19R)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2S)-2-amino-3-phenylpropanoyl]amino]-10-[3-(diaminomethylideneamino)propyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide |
| Synonym | Connective tissue-activating peptide. |
| Solubility | Soluble in water (1 mg/mL). |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Perry CJ, McNally GP. A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking. Eur J Neurosci. 2013 Sep;38(5):2762-73. PMID: 23773238.
Saccani F, Anselmi L, Jaramillo I, et al. Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice. J Neurosci Res. 2012 Nov;90(11):2146-53. PMID: 22806643.
Distrutti E, Cipriani S, Renga B, et al. Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Mol Pain. 2010 Jun 11;6:36. PMID: 20540729.