LKT Labs

Biochemicals for Life Science Research

Cyclophosphamide Monohydrate

Product ID C9609
Cas No. 6055-19-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $62.50 In stock
5 g $198.00 In stock
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Description

Cyclophosphamide is a nitrogen mustard that acts as an alkylator, adding alkyl groups to the N7 nitrogen of guanine bases; this inhibits DNA repair and replication. Cyclophosphamide exhibits anticancer chemotherapeutic and immunomodulatory activities. This compound is one component in the CHOP chemotherapy regimen. Cyclophosphamide is clinically used to treat various cancers, graft-versus-host disease (GvHD), and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous (SLE).

Product Info

Cas No.

6055-19-2
Purity

≥98%
Formula

C7H15Cl2N2O2P • H2O
Formula Wt.

279.10
Chemical Name

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-ox- azaphosphorin-2-amine 2 oxide monohydrate
IUPAC Name

N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate
Synonym

Cycloblastin, Cyclostin, Cytoxan, Endoxan

Melting Point

41-45°C
Solubility

Soluble in water. Slightly soluble in ethanol.
Appearance

White crystalline powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9609 MSDS PDF
Info Sheet

C9609 Info Sheet PDF

References

Sistigu A, Viaud S, Chaput N, et al. Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol. 2011 Jul;33(4):369-83. PMID: 21611872.

Makhani N, Gorman MP, Branson HM, et al. Cyclophosphamide therapy in pediatric multiple sclerosis. Neurology. 2009 Jun 16;72(24):2076-82. PMID: 19439723.

Hall AG, Tilby MJ. Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies. Blood Rev. 1992 Sep;6(3):163-73. PMID: 1422285.

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