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Cyclosporin B

Cyclosporin B

Product ID C9615
Cas No. 63775-95-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $293.20 In stock
10 mg $525.90 In stock
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  • Description
  • Product Info
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Description

Cyclosporin B is a derivative of cyclosporin A that exhibits significantly less immunosuppressive activity. Cyclosporin B displays antiviral properties, inhibiting entry of hepatitis B into hepatocytes. Cyclosporin B also inhibits RANKL-induced TRAP phosphatase activity, inducing apoptosis in osteoclasts.

Product Info

Cas No.

63775-95-1

Purity

≥95%

Formula

C61H109N11O12

Formula Wt.

1188.59

Chemical Name

Ala2-cyclosporine

IUPAC Name

(3S,6S,9S,12S,15R,18S,21S,24S,30S, 33R)-33-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28, 30-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1, 4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17, 20,23,26,29,32-undecone InChI: InChI=1S/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79) 66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44 (29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81) 70(22)46(31-36(8)9)59(82)71(23)49(38(12)13)61(84)72(50)24/h25-26,33-46, 48-51,74H,27-32H2,1-24H3,(H,62,76)(H,63,75)(H,64,78)(H,65, 77)/b26-25+/t39?,40-,41+,42+,43+,44+,45+,46+,48+,49+,50-,51?/m1/s1

Melting Point

149-152°C

Solubility

Soluble in methanol, ethanol and acetone.

Appearance

Amorphous white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C9615 MSDS PDF

Info Sheet

C9615 Info Sheet PDF

References

Iwamoto M, Watashi K, Tsukuda S, et al. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 2014 Jan 17;443(3):808-13. PMID: 24342612.

Igarashi K, Hirotani H, Woo JT, et al. Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone. 2004 Jul;35(1):47-56. PMID: 15207740.

Custom Order

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