LKT Labs

Biochemicals for Life Science Research

Cytochalasin D

Cytochalasin D

Product ID C9881
Cas No. 22144-77-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $236.00 In stock
5 mg $977.00 Please Inquire
Bulk Quote

Quicklinks

Description

Cytochalasin D is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin D exhibits anti-angiogenic and pro-oxidative activities. In endothelial cells, cytochalasin D inhibits FGF- and VEGF-induced angiogenesis. In other cellular models, cytochalasin D increases production of ROS and activity of NADPH oxidase. Additionally, this compound increases levels of PPARγ, lipoprotein lipase, and FABP4, controlling adipogenesis in stem cells through its effects on cytoskeletal tension.

Product Info

Cas No.

22144-77-0
Purity

≥98%
Formula

C30H37NO6
Formula Wt.

507.62
IUPAC Name

[(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
Melting Point

255°C (dec)
Appearance

White Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9881 MSDS PDF
Info Sheet

C9881 Info Sheet PDF

References

Wilkins JR, Pike DB, Gibson CC, et al. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog. 2014 Feb 14. [Epub ahead of print]. PMID: 24574264.

Choy JS, Lu X, Yang J, et al. Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H69-77. PMID: 24186098.

Schiller ZA, Schiele NR, Sims JK, et al. Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro. Stem Cell Res Ther. 2013 Jul 9;4(4):79. PMID: 23838354.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • Z1970

    Zerumbone

    Cyclic sesquiterpene found in ginger root; pote...

    ≥99%
  • V3325

    Virginiamycin M1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥97%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • Z161022

    α-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • D1995

    Dexrazoxane Hydrochloride

    Iron chelator.

    ≥98%
  • A7202

    AS-604850

    p110γ PI3K inhibitor.

    ≥98%
  • D3203

    Diallyl Tetrasulfide

    Organosulfur found in garlic; Microtubule polym...

    ≥90%
  • M1845

    Melitracen Hydrochloride

    Tricyclic antidepressant; potential D1/2 antago...

    ≥99%
  • A4850

    [His18]-Amylin, rat

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • E6376

    Eptifibatide

    Glycoprotein IIb/IIIa inhibitor.

    ≥98%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • K1655

    Kenpaullone

    GSK-3β, HGK, and CDK inhibitor.

    ≥95%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • E6257

    Epothilone B

    Microtubule depolymerization inhibitor.

    ≥98%
  • E5210

    Endomorphin-1

    Endogenous opioid peptide; μOr agonist.

    ≥95%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • P2919

    L-Phenylalaninol

    Non-essential amino acid alcohol.

    ≥98%
  • O9397

    Oxytetracycline Hydrochloride

    Tetracycline; protein translation inhibitor.

    ≥95%