LKT Labs

Biochemicals for Life Science Research

Cytochalasin D

Cytochalasin D

Product ID C9881
Cas No. 22144-77-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $236.40 In stock
5 mg $976.60 Please Inquire
Bulk Quote

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Description

Cytochalasin D is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin D exhibits anti-angiogenic and pro-oxidative activities. In endothelial cells, cytochalasin D inhibits FGF- and VEGF-induced angiogenesis. In other cellular models, cytochalasin D increases production of ROS and activity of NADPH oxidase. Additionally, this compound increases levels of PPARγ, lipoprotein lipase, and FABP4, controlling adipogenesis in stem cells through its effects on cytoskeletal tension.

Product Info

Cas No.

22144-77-0
Purity

≥98%
Formula

C30H37NO6
Formula Wt.

507.62
IUPAC Name

[(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
Melting Point

255°C (dec)
Appearance

White Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9881 MSDS PDF
Info Sheet

C9881 Info Sheet PDF

References

Wilkins JR, Pike DB, Gibson CC, et al. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog. 2014 Feb 14. [Epub ahead of print]. PMID: 24574264.

Choy JS, Lu X, Yang J, et al. Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H69-77. PMID: 24186098.

Schiller ZA, Schiele NR, Sims JK, et al. Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro. Stem Cell Res Ther. 2013 Jul 9;4(4):79. PMID: 23838354.

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