Description
Cytochalasin D is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin D exhibits anti-angiogenic and pro-oxidative activities. In endothelial cells, cytochalasin D inhibits FGF- and VEGF-induced angiogenesis. In other cellular models, cytochalasin D increases production of ROS and activity of NADPH oxidase. Additionally, this compound increases levels of PPARγ, lipoprotein lipase, and FABP4, controlling adipogenesis in stem cells through its effects on cytoskeletal tension.