LKT Labs

Biochemicals for Life Science Research

Cytochalasin D

Cytochalasin D

Product ID C9881
Cas No. 22144-77-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $236.40 In stock
5 mg $976.60 Please Inquire
Bulk Quote

Quicklinks

Description

Cytochalasin D is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin D exhibits anti-angiogenic and pro-oxidative activities. In endothelial cells, cytochalasin D inhibits FGF- and VEGF-induced angiogenesis. In other cellular models, cytochalasin D increases production of ROS and activity of NADPH oxidase. Additionally, this compound increases levels of PPARγ, lipoprotein lipase, and FABP4, controlling adipogenesis in stem cells through its effects on cytoskeletal tension.

Product Info

Cas No.

22144-77-0
Purity

≥98%
Formula

C30H37NO6
Formula Wt.

507.62
IUPAC Name

[(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
Melting Point

255°C (dec)
Appearance

White Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C9881 MSDS PDF
Info Sheet

C9881 Info Sheet PDF

References

Wilkins JR, Pike DB, Gibson CC, et al. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog. 2014 Feb 14. [Epub ahead of print]. PMID: 24574264.

Choy JS, Lu X, Yang J, et al. Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H69-77. PMID: 24186098.

Schiller ZA, Schiele NR, Sims JK, et al. Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro. Stem Cell Res Ther. 2013 Jul 9;4(4):79. PMID: 23838354.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P6854

    Progesterone

    Endogenous steroid hormone involved in reproduc...

    ≥98%
  • A7618

    Atenolol

    β1-adrenergic antagonist.

    ≥98%
  • P3348

    Pimecrolimus

    Calcineurin inhibitor, potential TRPV1 agonist....

    ≥99%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • C1600

    Carcinoembryonic Antigen (605-613)

    Carcinoembryonic antigen epitope.

    ≥95%
  • E6995

    Erythromycin Ethylsuccinate

    Macrolide; protein translation inhibitor, mamma...

    ≥97%
  • M3344

    Milrinone

    PDE3 inhibitor.

    ≥98%
  • B030960

    BAY-1082439

    PI3K inhibitor.

    ≥98%
  • T0090

    7-(Triethylsilyl)-baccatin III

    Synthetic taxol synthesis intermediate; microtu...

    ≥98%
  • L186858

    Levomefolic acid

    Folic acid derivative

    ≥98%
  • H000051

    H-151

    STING antagonist

    ≥99%
  • D183745

    Destruxin B

    Cyclic depsipeptide is a secondary metabolite i...

    ≥96%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • P8118

    Puerarin

    Isoflavone daidzein derivative found in Puerari...

    ≥96%
  • N5768

    Norfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A2532

    AGI-6780

    Isocitrate dehydrogenase inhibitor.

    ≥98%
  • S7618

    StemRegenin 1 Hydrochloride

    AhR antagonist.

    ≥98%
  • V1868

    Veratramine

    Steroidal alkaloid found in Veratrum and Fritil...

    ≥98%