LKT Labs

Biochemicals for Life Science Research

Dasatinib

Dasatinib

Product ID D023721
Cas No. 302962-49-8
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $48.00 In stock
100 mg $89.00 In stock
250 mg $239.00 In stock
Bulk Quote

Quicklinks

Description

Dasatinib is an anticancer chemotherapeutic compound that inhibits Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others). Dasatinib is clinically used to treat chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL); in acute myelogenous leukemia (AML) cells, dasatinib induces myeloid differentiation and autophagy. Dasatinib also displays antiviral activity, preventing dengue virus infection through its inhibition of FYN kinase.

Product Info

Cas No.

302962-49-8
Purity

≥99%
Formula

C22H26ClN7O2S
Formula Wt.

488.01
IUPAC Name

N-(2-Chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl}amino)-1,3-thiazole-5-carboxamide
Synonym

BMS354825, BMS-354825, Sprycel

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

D023721 MSDS PDF
Info Sheet

D023721 Info Sheet PDF

References

Xie N, Zhong L, Liu L, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014 May 1;89(1):74-85. PMID: 24607273.

de Wispelaere M, LaCroix AJ, Yang PL. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. PMID: 23616652.

Montero JC, Seoane S, Ocaña A, et al. Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin Cancer Res. 2011 Sep 1;17(17):5546-52. PMID: 21670084.

Das J, Chen P, Norris D, et al. 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32. PMID: 17154512.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R1876

    all-trans-Retinol

    Diterpene component of vitamin A, differentiati...

    ≥95%
  • A480000

    AM251

    CB1 receptor antagonist/ inverse agonist.

    ≥97%
  • F8149

    Fumonisin B1

    Mycotoxin produced by Fusarium; sphingosine acy...

    ≥98%
  • S761025

    Stauprimide

    Analog of staurosporine.

    ≥98%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • A2044

    Aflatoxin B1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • G0248

    (-)-Gambogic Acid

    Xanthone found in Garcinia hanburyi.

    ≥99%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%
  • L5873

    Losartan Potassium

    AT1 antagonist.

    ≥98%
  • G8850

    GW-5074

    c-Raf inhibitor.

    ≥98%
  • A5037

    Amiodarone Hydrochloride

    Voltage-gated Na+, Ca2+, K+ channel blocker, α...

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • B4514

    Bleomycin A5 Hydrochloride Cu

    Induces apoptosis, DNA cleavage and strand brea...

    ≥85%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; g...

    ≥98%
  • A6970

    Artemether

    Sesquiterpene lactone derived from Artemesia.

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • D3209

    Diclofenac Sodium

    NSAID; COX-1/2 inhibitor, potential K+ channel ...

    ≥99%
  • E499601

    Empagliflozin

    SGLT2 inhibitor

    ≥98%
  • S1848

    Se-Methylseleno-L-cysteine

    Found in plants in Astragalus, Allium, and Bras...

    ≥98%
  • B9700

    BYL719

    p110α PI3K inhibitor.

    ≥99%, ≥99%ee