Description
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Product Unit Size | Cost | Quantity | Stock |
---|
Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.
Cas No. | 1073154-85-4 |
---|---|
Purity | ≥98% |
Formula | C20H21F3N8O3S |
Formula Wt. | 510.49 |
IUPAC Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide |
Synonym | VS-6063, PF-04554878 |
Solubility | DMSO 5 mg/mL warmed (9.79 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Lee BY, Timpson P, Horvath LG, et al. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 2015 Feb;146C:132-149. PMID: 25316657.
Kang Y, Hu W, Ivan C, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. PMID: 24062525.
Endogenous tripeptide, involved in HPA signalin...
Phase II enzyme inducer; Nrf2 activator; antiox...
PDGFR inhibitor.
Macrolide; protein translation inhibitor.
Peptide, derivative of AT I, cleavage product o...
May induce apoptosis in lymphoma cell lines.
Mycotoxin contaminant found in cereal grains.
Macrolide; protein synthesis inhibitor.
VEGFR inhibitor.
BHA derivative.
Endogenous peptide hormone, involved in feeding...
Phenol found in various plant sources, used to ...
Cell membrane permeability modulator, topoisome...
AMPK activator.
Synthetic peptide, vasopressin derivative; V2 a...
ITC, erysolin analog.
Fibrate; PPARα agonist, enoyl-CoA reductase in...
LRRK2 inhibitor.
Oxidized non-cylic hexose sugar.
Enalapril analog; ACE inhibitor.