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Defactinib

Defactinib

Product ID D1722
Cas No. 1073154-85-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $109.20 In stock
25 mg $315.00 In stock
100 mg $630.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Defactinib inhibits FAK and displays anticancer activity. In ovarian cancer models, this compound decreases cell proliferation, induces apoptosis, and decreases tumor weight.

Product Info

Cas No.

1073154-85-4

Purity

≥98%

Formula

C20H21F3N8O3S

Formula Wt.

510.49

IUPAC Name

N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

Synonym

VS-6063, PF-04554878

Solubility

DMSO 5 mg/mL warmed (9.79 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D1722 MSDS PDF

Info Sheet

D1722 Info Sheet PDF

References

Lee BY, Timpson P, Horvath LG, et al. FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 2015 Feb;146C:132-149. PMID: 25316657.

Kang Y, Hu W, Ivan C, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. PMID: 24062525.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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