LKT Labs

Biochemicals for Life Science Research

[Des-Pro2]-Bradykinin

[Des-Pro2]-Bradykinin

Product ID B6808
Cas No. 80943-05-1
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $98.40 Please Inquire
10 mg $167.80 Please Inquire
25 mg $294.60 Please Inquire
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Description

Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro, bradykinin decreases H2O2-induced senescence, increases activity of superoxide dismutase (SOD), and suppresses DNA damage, ROS production, and NADPH oxidase activity. Additionally, bradykinin increases expression of VEGF and promotes tube formation in prostate cancer cells.

Product Info

Cas No.

80943-05-1
Purity

≥95%
Formula

C45H66N14O10
Formula Wt.

963.12
Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B6808 MSDS PDF
Info Sheet

B6808 Info Sheet PDF

References

Mamenko M, Zaika O, Pochynyuk O. Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):122-9. PMID: 24378775.

Yu HS, Wang SW, Chang AC, et al. Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells. Biochem Pharmacol. 2014 Jan 15;87(2):243-53. PMID: 24225154.

Dong R, Xu X, Li G, et al. Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. PLoS One. 2013 Oct 25;8(10):e77034. PMID: 24204728.

Feher A, Cassuto J, Szabo A, et al. Increased tissue angiotensin-converting enzyme activity impairs bradykinin-induced dilation of coronary arterioles in obesity. Circ J. 2013;77(7):1867-76. PMID: 23603844.

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