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Dextromethorphan Hydrobromide Hydrate

Dextromethorphan Hydrobromide Hydrate

Product ID D1792
Cas No. 6700-34-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $68.70 In stock
10 g $120.20 In stock
50 g $469.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dextromethorphan exhibits anti-tussive, hallucinogenic, neuromodulatory, neuroprotective, anticonvulsant/antiepileptic, and anti-osteoporotic activities. Dextromethorphan acts as a full antagonist at serotonin transporters (SERTs), norepinephrine transporters (NETs), α3β4, α4β2, and α7 nicotinic acetylcholine receptors (nAChRs), and NADPH oxidase; it also acts as a weak antagonist at NMDA receptors. Additionally, dextromethorphan acts as a full agonist at σ1/2 receptors and as a weak agonist at μ/κ/δ opioid receptors. Dextromethorphan is commonly used in over-the-counter cough medicines. In animal models of Parkinson’s disease, dextromethorphan inhibits endotoxin-induced dopaminergic neurodegeneration. In electroshock assays, this compound inhibits the development of seizures. Dextromethorphan also inhibits RANKL-induced osteoclastogenesis and prevents bone loss in vivo.

Product Info

Cas No.

6700-34-1

Purity

≥98%

Formula

C18H25NO • HBr • H2O

Formula Wt.

370.3

Chemical Name

D-(+)-3-methoxy-17-methyl- (9α,13α,14α)- morphinan

IUPAC Name

(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;hydrate;hydrobromide

Synonym

( )-3-Methoxy-N-methylmorphinon, delta-Methorphan

Melting Point

116-120°C

Solubility

Soluble in water (15 mg/mL).

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1792 MSDS PDF

Info Sheet

D1792 Info Sheet PDF

References

Burns JM, Boyer EW. Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. PMID: 24648790.

Wu K, Lin TH, Liou HC, et al. Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Osteoporos Int. 2013 Aug;24(8):2201-14. PMID: 23400250.

Damaj MI, Flood P, Ho KK, et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. PMID: 15356218.

Zhang W, Wang T, Qin L, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. PMID: 14734632.

Chou YC, Liao JF, Chang WY, et al. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. PMID: 10064839.

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