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Diacerein

Diacerein

Product ID D3303
Cas No. 13739-02-1
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $126.50 Please Inquire
250 mg $464.90 Please Inquire
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Diacerein is an anthraquinone that exhibits antinociceptive, anti-inflammatory, and anti-resorptive activities. Diacerein is clinically used to treat osteoarthritis. In vivo, diacerein inhibits IL-1β as well as somatic nociception induced by glutamate, NMDA, and kainate. In vitro, diacerein decreases expression of matrix metalloproteinase 13 (MMP13), cathepsin K, ERK1/2, and p38 MAPK, resulting in decreases in the synthesis of resorptive factors and in osteoclast formation. In other cellular models, diacerein inhibits IL-1.

Product Info

Cas No.

13739-02-1

Purity

≥98%

Formula

C19H12O8

Formula Wt.

368.29

IUPAC Name

4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid

Synonym

diacetylrhein

Melting Point

217-218°C

Appearance

Bright yellow solid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3303 MSDS PDF

Info Sheet

D3303 Info Sheet PDF

References

Gadotti VM, Martins DF, Pinto HF, et al. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice. Pharmacol Biochem Behav. 2012 Oct;102(4):549-54. PMID: 22750064.

Boileau C, Tat SK, Pelletier JP, et al. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. Arthritis Res Ther. 2008;10(3):R71. PMID: 18578867.

Fidelix TS, Soares BG, Trevisani VF. Diacerein for osteoarthritis. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD005117. PMID: 16437519.

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