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Dimethyl Fumarate

Dimethyl Fumarate

Product ID D3448
Cas No. 624-49-7
Purity ≥98%
Product Unit SizeCostQuantityStock
25 g $37.60 In stock
100 g $105.30 In stock
250 g $165.40 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dimethyl fumarate is a fumaric acid methyl ester that is clinically used to treat psoriasis and under investigation as a potential treatment for multiple sclerosis (MS). Dimethyl fumarate exhibits immunomodulatory, antioxidative, and anti-inflammatory activities. In vitro, dimethyl fumarate increases expression of heme oxygenase 1 (HO-1) and Nrf2 and decreases proliferation of T cells and release of inflammatory cytokines. Dimethyl fumarate activates nicotinic acetylcholine receptors (nAChRs), although the relevance of this activity is unknown. Previously, this compound has been used as a radiosensitizer. Recently, dimethyl fumarate has displayed efficacy in models of multiple sclerosis, decreasing relapse and improving neurologic outcomes.

Product Info

Cas No.

624-49-7

Purity

≥98%

Formula

C6H8O4

Formula Wt.

144.13

IUPAC Name

dimethyl (E)-but-2-enedioate

Synonym

BG-12

Melting Point

102-104°C

Solubility

Soluble in water (1.6 mg/ml at 20° C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25° C), DMSO (29 mg/ml at 25° C), and DMF (~12 mg/ml)

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3448 MSDS PDF

Info Sheet

D3448 Info Sheet PDF

References

Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012 Sep 20;367(12):1087-97. Erratum in: N Engl J Med. 2012 Oct 25;367(17):1673. PMID: 22992072.

Scannevin RH, Chollate S, Jung MY, et al. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. PMID: 22267202.

Lehmann JC, Listopad JJ, Rentzsch CU, et al. Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. J Invest Dermatol. 2007 Apr;127(4):835-45. PMID: 17235328.

Held KD, Epp ER, Clark EP, et al. Effect of dimethyl fumarate on the radiation sensitivity of mammalian cells in vitro. Radiat Res. 1988 Sep;115(3):495-502. PMID: 3174933.

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