Description
Cycloheptylaminomethylene diphosphate is a bisphosphonate compound that inhibits squalene synthase and sterol biosynthesis in vitro and in vivo. In various immune cells, this compound increases caspase-mediated apoptosis. Like other bisphosphonates, this compound is known for its use in preventing bone resorption and bone loss. In vivo, this compound inhibits osteoclast-mediated bone resorption and prevents bone loss due to immobilization. When administered chronically, this compound delays fracture healing in vivo, but improves stiffness and ultimate load of the fractured bone; it does not prevent bone formation.