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DMH-1 is a bone morphogeneic protein (BMP) type-1 inhibitor and an analog of dorsomorphin. It is a potent inhibitor of activin receptor-like kinase 2 (ALK2). DMH-1 also promotes neurogenesis in human induced pluripotent stem cells when used in combination with SB4-31542, a TGF-β1 inhibitor.
| Cas No. | 1206711-16-1 |
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| Purity | ≥99% |
| Formula | C24H20N4O |
| Formula Wt. | 380.45 |
| Chemical Name | 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| IUPAC Name | 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |
| Synonym | DMH1; 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Mohedas A., Xing X., et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 8(6):1291-302 (2013). PMID: 23547776.
Neely D., Litt M., et al. DMH1, a Highly Selective Small Molecule BMP Inhibitor Promotes Neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 Expression during Neural Induction. 3(6):482-491 (2012). PMID: 22860217.