• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(E)-4-Hydroxytamoxifen

(E)-4-Hydroxytamoxifen

Product ID H9712
Cas No. 174592-47-3
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $214.10 In stock
10 mg $356.90 In stock
25 mg $743.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

(E)-4-Hydroxytamoxifen is the less active isomer of 4-hydroxytamoxifen. 4-Hydroxytamoxifen is the active metabolite of tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2+ amplitude, slowing relaxation and decreasing contractility.

Product Info

Cas No.

174592-47-3

Purity

≥97%

Formula

C26H29NO2

Formula Wt.

387.51

IUPAC Name

4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9712 MSDS PDF

Info Sheet

H9712 Info Sheet PDF

References

Asp ML, Martindale JJ, Metzger JM. Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling. PLoS One. 2013 Oct 24;8(10):e78768. PMID: 24205315.

Kohli L, Kaza N, Coric T, et al. 4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res. 2013 Jul 15;73(14):4395-405. PMID: 23722551.

Schwartz JA, Zhong L, Deighton-Collins S, et al. Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-alpha alter its response to estradiol and 4-hydroxytamoxifen. J Biol Chem. 2002 Apr 12;277(15):13202-9. Erratum in: J Biol Chem 2002 Jul 5;277(27):24842. PMID: 11823467.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S771339

    STING Agonist-12

    STING activator

    ≥99%
  • P4008

    PKC412

    Staurosporine derivative; PKC and FLT3 inhibito...

    ≥98%
  • A0817

    D,L-1’-Acetoxychavicol acetate

    TRPA1 agonist, xanthine oxidase inhibitor.

    ≥98%
  • V0376

    Vatalanib Dihydrochloride

    VEGFR inhibitor.

    ≥98%
  • V5725

    Voglibose

    α-glucosidase inhibitor, potential GLP-1 agoni...

    ≥99%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • M0368

    Marbofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P7318

    Pseudoginsenoside F11

    Saponin found in species of Panax; PPARγ agoni...

    ≥98%
  • F1854

    Fenticonazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • G7242

    GSK-690693

    Akt inhibitor.

    ≥99%
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • P1852

    Penicillin G procaine

    Hydrophobic β-lactam; penicillin binding prote...

    ≥98%
  • T564093

    (+)-δ-Tocopherol

    Vitamin E component

    ≥98%
  • D3228

    Dihydromyristicin

    Found in parsley.

    ≥98%
  • S8145

    Sulindac

    NSAID; COX-1/2 and PDE inhibitor.

    ≥99%
  • S0278

    Satraplatin

    Pt-based DNA cross-linker.

    ≥98%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • A6826

    L-Arginine Hydrochloride

    Endogenous amino acid, also found in meat, dair...

    ≥98%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only