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Endothelin-2 is an endogenous peptide agonist at endothelin A and B (ET-A/B) receptors that exhibits anti-angiogenic and vasoconstrictive activities. Endothelin-2 inhibits endothelial cell migration and invasion, suppressing vascular development in the retina. In arteries, this peptide induces vasoconstriction in a PLC/ROCK-dependent manner. Additionally, endothelin-2 promotes myelination in animal models.
| Cas No. | 123562-20-9 |
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| Purity | ≥95% |
| Formula | C115H160N26O32S4 |
| Formula Wt. | 2546.97 |
| Solubility | Soluble in water (1 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Compeer MG, Janssen GM, De Mey JG. Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries. Br J Pharmacol. 2013 Nov;170(6):1199-209. PMID: 23941276.
Rattner A, Yu H, Williams J, et al. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-9. PMID: 24043815.
Yuen TJ, Johnson KR, Miron VE, et al. Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. Brain. 2013 Apr;136(Pt 4):1035-47. PMID: 23518706.