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Erdosteine is a thiol derivative that is clinically used to treat bronchitis and chronic obstructive lung diseases; it exhibits mucolytic, antioxidative, and anti-inflammatory activities. In vitro, erdosteine inhibits H2O2-induced oxidative stress and DNA damage in vitro by scavenging ROS. Additionally, this compound decreases levels of leukotriene B4 (LTB4) and leukotriene E4 (LTE4) in clinical subjects with chronic obstructive pulmonary disease (COPD).
| Cas No. | 84611-23-4 |
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| Purity | ≥98% |
| Formula | C8H11NO4S2 |
| Formula Wt. | 249.31 |
| Chemical Name | [[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]- thio]acetic acid |
| IUPAC Name | 2-[2-oxo-2-[(2-oxothiolan-3-yl)amino]ethyl]sulfanylacetic acid |
| Synonym | RV-144, Secresolv |
| Melting Point | 156-158°C |
| Solubility | Slightly soluble in water, methanol or ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Marabini L, Calò R, Braga PC. Protective effect of erdosteine metabolite I against hydrogen peroxide-induced oxidative DNA-damage in lung epithelial cells. Arzneimittelforschung. 2011;61(12):700-6. PMID: 22282957.
Dal Negro RW, Visconti M, Tognella S, et al. Erdosteine affects eicosanoid production in COPD. Int J Clin Pharmacol Ther. 2011 Jan;49(1):41-5. PMID: 21176724.