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Felodipine

Felodipine

Product ID F1745
Cas No. 72509-76-3
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $141.00 In stock
100 mg $225.30 In stock
250 mg $422.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Felodipine is a dihydropyridine antagonist at L-type cardiac Ca2+ channels. Felodipine exhibits antihypertensive, cardioprotective, and anti-inflammatory activities. In rat models of metabolic syndrome, felodipine decreases blood pressure, activation of NF-κB, and levels of serum insulin, ICAM-1, VCAM-1, and circulating macrophages. In animal models of cardiac ischemia/reperfusion, felodipine decreases infarct size.

Product Info

Cas No.

72509-76-3

Purity

≥98%

Formula

C18H19Cl2NO4

Formula Wt.

384.25

IUPAC Name

5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3, 5-dicarboxylate

Synonym

Flodil, Munobal, Penedil, Perfudal, Plendil

Melting Point

142-145°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F1745 MSDS PDF

Info Sheet

F1745 Info Sheet PDF

References

Tan HW, Xing SS, Bi XP, et al. Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation. Acta Pharmacol Sin. 2008 Sep;29(9):1051-9. PMID: 18718174.

Kal JE, Spaan JA, van Wezel HB. Calcium channel blockade with felodipine does not affect metabolic coronary vasodilation in patients with coronary artery disease. J Cardiovasc Pharmacol. 2002 Feb;39(2):225-33. PMID: 11791008.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

Custom Order

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