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Fenoldopam is a benzazepine derivative that acts as a partial agonist at D1 receptors; it may also inhibit α1-adrenergic receptors. Fenoldopam exhibits vasodilatory, antihypertensive, and natriuretic activities. In vivo, fenoldopam decreases blood pressure, afterload, and blood flow; it also inhibits NaCl reabsorption in the thick ascending limb, promoting Na+ excretion.
| Cas No. | 67227-57-0 |
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| Purity | ≥98% |
| Formula | C16H16ClNO3S • CH3SO3H |
| Formula Wt. | 401.87 |
| Chemical Name | 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H- 3-benzazepine-7,8-diol methanesulfonate |
| IUPAC Name | 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7, 8-diol;methanesulfonic acid |
| Synonym | Fenoldopam methanesulfonate, Corlopam |
| Melting Point | 274°C (dec) |
| Solubility | Soluble in water. DMSO 15 mg/mL. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Grider JS, Ott CE, Jackson BA. Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. Eur J Pharmacol. 2003 Jul 25;473(2-3):185-90. PMID: 12892837.
Schafer JA, Li L, Sun D. The collecting duct, dopamine and vasopressin-dependent hypertension. Acta Physiol Scand. 2000 Jan;168(1):239-44. PMID: 10691807.
Martin SW, Broadley KJ. Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade. Br J Pharmacol. 1995 May;115(2):349-55. PMID: 7670737.
Grenader A, Healy DP. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. PMID: 1677038.
Nichols AJ, Ruffolo RR Jr, Brooks DP. The pharmacology of fenoldopam. Am J Hypertens. 1990 Jun;3(6 Pt 2):116S-119S. PMID: 1974439.