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Fexaramine

Fexaramine

Product ID F1992
Cas No. 574013-66-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $185.10 In stock
25 mg $643.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fexaramine is a gut-restricted agonist at farnesoid X receptors (FXRs) that displays anti-obesity activity. Fexaramine alters bile acid composition, decreases weight gain and glucose production, and increases white adipose thermogenesis in animal models.

Product Info

Cas No.

574013-66-4

Purity

≥98%

Formula

C32H36N2O3

Formula Wt.

496.65

Chemical Name

(E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate

IUPAC Name

Methyl (2E)-3-{3-[(cyclohexylcarbonyl){[4'-(dimethylamino)-4-biphenylyl]methyl}amino]phenyl}acrylate

Synonym

CHEMBL192966; CHEBI:80003

Solubility

100mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F1992 MSDS PDF

Info Sheet

F1992 Info Sheet PDF

References

Fang S, Suh JM, Reilly SM, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65. PMID: 25559344.

Downes M, Verdecia MA, Roecker AJ, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92. PMID: 12718892.

Custom Order

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