LKT Labs

Biochemicals for Life Science Research

Flavopiridol Hydrochloride

Flavopiridol Hydrochloride

Product ID F441026
Cas No. 131740-09-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $134.00 In stock
25 mg $443.00 In stock
Bulk Quote

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Description

Flavopiridol hydrochloride is a plant-derived semisynthetic flavone that acts as a cycline-dependent kinase inhibitor. Flavopiridol was found to induce apoptosis in chronic lymphocytic leaukemia cells in vitro, but significant toxicity has prevented further development as a single agent treatment. A combination treatment using cytarabine and mitoxantrone in addition to flavopiridol against acute myeloid leukemia in vivo has also been evaluated. Further studies have found flavopiridol to elicit anti-inflammatory activity via CDK9 and NFkB-dependent signaling.

Product Info

Cas No.

131740-09-5
Purity

≥98%
Formula

C21H21Cl2NO5
Formula Wt.

438.30
IUPAC Name

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride

Synonym

Flavopiridol HCl; Alvocidib hydrochloride; Alvocidib HCl

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F441026 MSDS PDF
Info Sheet

F441026 Info Sheet PDF

References

Wiernik PH. Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia. Expert Opin Investig Drugs. 2016 Jun;25(6):729-734. PMID: 26998706.

Zeidner JF, Karp JE. Clinical activity of alvociclib (flavopiridol) in acute myeloid leukemia. Leuk Res. 2015 Dec;39(12):1312-1318. PMID: 26521988.

Srikumar T, Padmanabhan J. Potential use of flavopiridol in treatment of chronic diseases. Adv Exp Med Biol. 2016;929:209-228. PMID: 27771926.

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