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Fludarabine

Fludarabine

Product ID F4781
Cas No. 21679-14-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $87.60 In stock
10 mg $126.30 In stock
25 mg $240.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fludarabine is a purine nucleoside analog of adenosine that is clinically used to treat leukemias such as chronic lymphocytic leukemia (CLL) and also to treat graft-versus-host disease (GVHD) in transplant patients. Fludarabine exhibits anticancer chemotherapeutic and immunosuppressive activities. Incorporation of fludarabine into DNA chains inhibits ribonucleotide reductase, DNA ligase, and DNA primase, inducing chain termination and preventing DNA synthesis. In vitro, fludarabine inhibits TNF-α-stimulated degradation of IκB kinase, preventing activation of NF-κB. This compound also induces cell cycle arrest and apoptosis in alloreactive bone marrow stromal cells. Like other adenosine analogs, fludarabine also acts as an antagonist at the A1 adenosine receptor.

Product Info

Cas No.

21679-14-1

Purity

≥98%

Formula

C10H12FN5O4

Formula Wt.

285.23

IUPAC Name

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol

Synonym

2-Fluoroadenine-9-b-D-arabinofuranoside

Melting Point

260°C

Solubility

Slightly soluble in water (3.5 mg/mL). Soluble in DMSO (100 mM)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4781 MSDS PDF

Info Sheet

F4781 Info Sheet PDF

References

Jensen K, Johnson LA, Jacobson PA, et al. Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. PMID: 22249336.

Nishioka C, Ikezoe T, Togitani K, et al. Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor kappaB. Bone Marrow Transplant. 2008 Feb;41(3):303-9. PMID: 17994120.

Gandhi V, Plunkett W. Cellular and clinical pharmacology of fludarabine. Clin Pharmacokinet. 2002;41(2):93-103. PMID: 11888330.

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