LKT Labs

Biochemicals for Life Science Research

Flufenamic Acid

Flufenamic Acid

Product ID F4483
Cas No. 530-78-9
Purity ≥97%
Product Unit SizeCostQuantityStock
10 g $41.00 In stock
50 g $102.00 In stock
Bulk Quote

Quicklinks

Description

Flufenamic acid is a COX-inhibiting non-steroidal anti-inflammatory drug (NSAID) that exhibits neuromodulatory, anti-inflammatory, antipyretic, analgesic, and antiepileptic/anticonvulsant activities. Flufenamic inhibits voltage-gated Na+ channels, transient receptor potential canonical 3 (TRPC3) channels, and transient receptor potential melastatin-like 2 (TRPM2) channels and potentiates TREK1 (KCNK2) channel activity. In vitro, flufenamic acid decreases glutamatergic excitatory activity and neuronal excitability.

Product Info

Cas No.

530-78-9
Purity

≥97%
Formula

C14H10F3NO2
Formula Wt.

281.23
Chemical Name

2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid

IUPAC Name

2-[3-(trifluoromethyl)anilino]benzoic acid
Synonym

Achless, Ansatin, Arlef, Fullsafe, Parlef, Sastridex, Tecramine
Melting Point

125°C

Solubility

Soluble in 4 parts of ethanol. Soluble in DMSO to 100 mM and in ethanol to 100 mM
Appearance

White to pale yellow powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

F4483 MSDS PDF
Info Sheet

F4483 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Xie YF, Zhou F. TRPC3 channel mediates excitation of striatal cholinergic interneurons. Neurol Sci. 2014 May 21. [Epub ahead of print]. PMID: 24844791.

Veale EL, Al-Moubarak E, Bajaria N, et al. Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels. Mol Pharmacol. 2014 May;85(5):671-81. PMID: 24509840.

Nazıroğlu M, Özgül C, Çelik Ö, et al. Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone. J Membr Biol. 2011 May;241(2):69-75. PMID: 21509529.

Yau HJ, Baranauskas G, Martina M. Flufenamic acid decreases neuronal excitability through modulation of voltage-gated sodium channel gating. J Physiol. 2010 Oct 15;588(Pt 20):3869-82. PMID: 20724367.

Fernández M, Lao-Peregrín C, Martín ED. Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability. Epilepsia. 2010 Mar;51(3):384-90. PMID: 19732136.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3575

    2,5-Di-tert-butyl-4-hydroxyanisole

    BHA derivative; potential Ca2+ ATPase inhibitor...

    ≥98%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%
  • C1844

    Celastrol

    Triterpene isolated Trypterigium wilfordii; HSP...

    ≥98%
  • P2858

    4-α-Phorbol-12-myristate-13-acetate

    Negative control for PKC activation.

    ≥98%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • G8225

    Guggulsterone

    Steroid found in myrrh; FXR antagonist.

    ≥98%
  • A0101

    4-bromo-A23187

    Non-fluorescent halogenated A23187 analog, Ca2+...

    ≥98%
  • E7556

    Etodolac

    NSAID; TRPA1 agonist, COX-2 inhibitor.

    ≥98%
  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • E5202

    Enalapril

    ACE inhibitor.

    ≥98%
  • T0100

    10-Deacetyltaxol

    Taxane found in Taxus; microtubule depolymeriza...

    ≥98%
  • E6995

    Erythromycin Ethylsuccinate

    Macrolide; protein translation inhibitor, mamma...

    ≥97%
  • B807214

    Buflomedil Hydrochloride

    Alpha blocker and vasoactive agent.

    ≥99%
  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • D3430

    Dihydrosanguinarine

    Benzophenanthridine alkaloid, sanguinarine meta...

    ≥98%
  • C0378

    Catharanthine Tartrate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥97%
  • Q8019

    Quetiapine Fumarate

    5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...

    ≥99%
  • C5771

    Corticosterone

    Endogenous steroid hormone involved in immune r...

    ≥98%
  • C1621

    CEF4

    Peptide, vSrc-induced cytokine.

    ≥95%