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Foretinib

Foretinib

Product ID F5968
Cas No. 849217-64-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $109.30 In stock
10 mg $164.00 In stock
25 mg $319.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Foretinib is an inhibitor of ROS1, MET, Ron, Axl, Tie-2, and VEGFR2 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In subjects with squamous cell carcinoma, foretinib decreases tumor size. In hepatocellular carcinoma cells, foretinib increases expression of p27 and Bim, decreases expression of cyclin B1 and p-c-Myc, and induces G2/M phase cell cycle arrest, inhibiting cell growth and migration as well as tumor growth and angiogenesis.

Product Info

Cas No.

849217-64-7

Purity

≥98%

Formula

C34H34F2N4O6

Formula Wt.

632.65

Chemical Name

1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

IUPAC Name

1-N'-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Synonym

GSK-1363089, GSK1363089; XL880

Solubility

Relatively insoluble in water and ethanol. Soluble in DMSO to 127 mg/mL.

Appearance

Off white to pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F5968 MSDS PDF

Info Sheet

F5968 Info Sheet PDF

References

Shah MA, Wainberg ZA, Catenacci DV, et al. Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer. PLoS One. 2013;8(3):e54014. PMID: 23516391.

Seiwert T, Sarantopoulos J, Kallender H, et al. Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Invest New Drugs. 2013 Apr;31(2):417-24. PMID: 22918720.

Huynh H, Ong R, Soo KC. Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis. 2012 Mar;15(1):59-70. PMID: 22187171.

Custom Order

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