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Galantide is a nonselective peptide antagonist at the galanin receptor. Galantide inhibits opioid-induced antinociception in vivo. Galantide exhibits neuromodulatory, cognition enhancing, and gastrointestinal motility modulating activities. In animal models, galantide improves memory function in social recognition tasks. Additionally, this compound induces contractions in gastric smooth muscle.
| Cas No. | 138579-66-5 |
|---|---|
| Purity | ≥95% |
| Formula | C104H151N25O26S |
| Formula Wt. | 2199.58 |
| Synonym | M15 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Sun YG, Yu LC. Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats. Regul Pept. 2005 Jan 15;124(1-3):37-43. PMID: 15544839.
Korolkiewicz RP, Konstanski Z, Rekowski P, et al. Mechanism of the contractile effects of galantide and Galanin(1-14) [alpha-aminobutyric acid]scyliorhinin-I in rat isolated fundus strips. Med Sci Monit. 2002 Jan;8(1):BR19-23. PMID: 11782668.
Arletti R, Benelli A, Cavazzuti E, et al. Galantide improves social memory in rats. Pharmacol Res. 1997 Apr;35(4):317-9. PMID: 9264048.